Overview
| Uniprot ID | Q9NZJ6 |
|---|
| Protein Name | Ubiquinone biosynthesis O-methyltransferase, mitochondrial |
|---|
| Gene Name | COQ3 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 196 |
SFDPVLDKRIEYRVC |
Function
O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis (By similarity) (PubMed:10777520, PubMed:38425362). Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-decaprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-decaprenyl)benzoic acid (By similarity) (PubMed:10777520, PubMed:38425362). Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone (By similarity) (PubMed:38425362). Also able to mediate the methylation of 3-demethylubiquinol-10 into ubiquinol-10 (By similarity) (PubMed:10777520)
Protein Sequence
10
MWSGRKLGSS
20
GGWFLRVLGP
30
GGCNTKAARP
40
LISSAVYVKN
50
QLSGTLQIKP
60
GVFNEYRTIW
70
FKSYRTIFSC
80
LNRIKSFRYP
90
WARLYSTSQT
100
TVDSGEVKTF
110
LALAHKWWDE
120
QGVYAPLHSM
130
NDLRVPFIRD
140
NLLKTIPNHQ
150
PGKPLLGMKI
160
LDVGCGGGLL
170
TEPLGRLGAS
180
VIGIDPVDEN
190
IKTAQCHKSF
200
DPVLDKRIEY
210
RVCSLEEIVE
220
ETAETFDAVV
230
ASEVVEHVID
240
LETFLQCCCQ
250
VLKPGGSLFI
260
TTINKTQLSY
270
ALGIVFSEQI
280
ASIVPKGTHT
290
WEKFVSPETL
300
ESILESNGLS
310
VQTVVGMLYN
320
PFSGYWHWSE
330
NTSLNYAAYA
340
VKSRVQEHPA
350
SAEFVLKGET
360
EELQANACTN
PAVHEKLKK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031314 |
extrinsic component of mitochondrial inner membrane |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0061542 |
3-demethylubiquinol 3-O-methyltransferase activity |
| Molecular Function |
GO:0120537 |
3-demethylubiquinone 3-O-methyltransferase activity |
| Molecular Function |
GO:0008171 |
O-methyltransferase activity |
| Molecular Function |
GO:0010420 |
polyprenyldihydroxybenzoate methyltransferase activity |
| Biological Process |
GO:0006071 |
glycerol metabolic process |
| Biological Process |
GO:0032259 |
methylation |
| Biological Process |
GO:0006744 |
ubiquinone biosynthetic process |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.