Search Results

Overview

Uniprot IDQ9NZJ9
Protein NameDiphosphoinositol polyphosphate phosphohydrolase 2
Gene NameNUDT4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
133 IKVLQCHKPVHAEYL

Function

Cleaves the beta-phosphate from diphosphoinositol polyphosphates such as PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 (diphosphoinositol tetrakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:10777568). Diadenosine polyphosphates, particularly Ap6A (P(1),P(6)-bis(5a-adenosyl) hexaphosphate) and Ap5A (P(1),P(5)-bis(5'-adenosyl) pentaphosphate) are downstream effectors of a signaling cascade that regulates cardiac KATP channels, can also be substrates, although with lower preference than the diphosphoinositol polyphosphates (PubMed:10777568). Can also catalyze the hydrolysis of 5-phosphoribose 1-diphosphate, generating the glycolytic activator ribose 1,5-bisphosphate (PubMed:12370170). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity)

Protein Sequence

10 MMKFKPNQTR 20 TYDREGFKKR 30 AACLCFRSEQ 40 EDEVLLVSSS 50 RYPDQWIVPG 60 GGMEPEEEPG 70 GAAVREVYEE 80 AGVKGKLGRL 90 LGIFENQDRK 100 HRTYVYVLTV 110 TEILEDWEDS 120 VNIGRKREWF 130 KVEDAIKVLQ 140 CHKPVHAEYL 150 EKLKLGCSPA 160 NGNSTVPSLP 170 DNNALFVTAA 180 QTSGLPSSVR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Molecular Function GO:0034431 bis(5'-adenosyl)-hexaphosphatase activity
Molecular Function GO:0034432 bis(5'-adenosyl)-pentaphosphatase activity
Molecular Function GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity
Molecular Function GO:0000298 endopolyphosphatase activity
Molecular Function GO:0052848 inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
Molecular Function GO:0052845 inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity
Molecular Function GO:0106211 inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0030515 snoRNA binding
Biological Process GO:1901911 adenosine 5'-(hexahydrogen pentaphosphate) catabolic process
Biological Process GO:0019722 calcium-mediated signaling
Biological Process GO:1901909 diadenosine hexaphosphate catabolic process
Biological Process GO:1901907 diadenosine pentaphosphate catabolic process
Biological Process GO:0071543 diphosphoinositol polyphosphate metabolic process
Biological Process GO:0035556 intracellular signal transduction

Reference

PMID: N/A