Search Results
Overview
| Uniprot ID | Q9NZK5 |
|---|---|
| Protein Name | Adenosine deaminase 2 |
| Gene Name | ADA2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 67 | NERLMTLKIAEMKEA |
Function
Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity
Protein Sequence
10
MLVDGPSERP
20
ALCFLLLAVA
30
MSFFGSALSI
40
DETRAHLLLK
50
EKMMRLGGRL
60
VLNTKEELAN
70
ERLMTLKIAE
80
MKEAMRTLIF
90
PPSMHFFQAK
100
HLIERSQVFN
110
ILRMMPKGAA
120
LHLHDIGIVT
130
MDWLVRNVTY
140
RPHCHICFTP
150
RGIMQFRFAH
160
PTPRPSEKCS
170
KWILLEDYRK
180
RVQNVTEFDD
190
SLLRNFTLVT
200
QHPEVIYTNQ
210
NVVWSKFETI
220
FFTISGLIHY
230
APVFRDYVFR
240
SMQEFYEDNV
250
LYMEIRARLL
260
PVYELSGEHH
270
DEEWSVKTYQ
280
EVAQKFVETH
290
PEFIGIKIIY
300
SDHRSKDVAV
310
IAESIRMAMG
320
LRIKFPTVVA
330
GFDLVGHEDT
340
GHSLHDYKEA
350
LMIPAKDGVK
360
LPYFFHAGET
370
DWQGTSIDRN
380
ILDALMLNTT
390
RIGHGFALSK
400
HPAVRTYSWK
410
KDIPIEVCPI
420
SNQVLKLVSD
430
LRNHPVATLM
440
ATGHPMVISS
450
DDPAMFGAKG
460
LSYDFYEVFM
470
GIGGMKADLR
480
TLKQLAMNSI
490
KYSTLLESEK
500
NTFMEIWKKR
510
WDKFIADVAT
K
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035578 | azurophil granule lumen |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0004000 | adenosine deaminase activity |
| Molecular Function | GO:0031685 | adenosine receptor binding |
| Molecular Function | GO:0008083 | growth factor activity |
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0043394 | proteoglycan binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006154 | adenosine catabolic process |
| Biological Process | GO:0046103 | inosine biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.