Search Results

Overview

Uniprot ID	Q9NZM1
Protein Name	Myoferlin
Gene Name	MYOF
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1013	KSWVAAEKMYHTHRR
16	ASNIPKTKFGKPDPI
1866	QLCIVAKKEHFWSID
407	EVSFAGKKVCTNIIE

Function

Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity)

Protein Sequence

10 MLRVIVESAS 20 NIPKTKFGKP 30 DPIVSVIFKD 40 EKKKTKKVDN 50 ELNPVWNEIL 60 EFDLRGIPLD 70 FSSSLGIIVK 80 DFETIGQNKL 90 IGTATVALKD 100 LTGDQSRSLP 110 YKLISLLNEK 120 GQDTGATIDL 130 VIGYDPPSAP 140 HPNDLSGPSV 150 PGMGGDGEED 160 EGDEDRLDNA 170 VRGPGPKGPV 180 GTVSEAQLAR 190 RLTKVKNSRR 200 MLSNKPQDFQ 210 IRVRVIEGRQ 220 LSGNNIRPVV 230 KVHVCGQTHR 240 TRIKRGNNPF 250 FDELFFYNVN 260 MTPSELMDEI 270 ISIRVYNSHS 280 LRADCLMGEF 290 KIDVGFVYDE 300 PGHAVMRKWL 310 LLNDPEDTSS 320 GSKGYMKVSM 330 FVLGTGDEPP 340 PERRDRDNDS 350 DDVESNLLLP 360 AGIALRWVTF 370 LLKIYRAEDI 380 PQMDDAFSQT 390 VKEIFGGNAD 400 KKNLVDPFVE 410 VSFAGKKVCT 420 NIIEKNANPE 430 WNQVVNLQIK 440 FPSVCEKIKL 450 TIYDWDRLTK 460 NDVVGTTYLH 470 LSKIAASGGE 480 VEDFSSSGTG 490 AASYTVNTGE 500 TEVGFVPTFG 510 PCYLNLYGSP 520 REYTGFPDPY 530 DELNTGKGEG 540 VAYRGRILVE 550 LATFLEKTPP 560 DKKLEPISND 570 DLLVVEKYQR 580 RRKYSLSAVF 590 HSATMLQDVG 600 EAIQFEVSIG 610 NYGNKFDTTC 620 KPLASTTQYS 630 RAVFDGNYYY 640 YLPWAHTKPV 650 VTLTSYWEDI 660 SHRLDAVNTL 670 LAMAERLQTN 680 IEALKSGIQG 690 KIPANQLAEL 700 WLKLIDEVIE 710 DTRYTLPLTE 720 GKANVTVLDT 730 QIRKLRSRSL 740 SQIHEAAVRM 750 RSEATDVKST 760 LAEIEDWLDK 770 LMQLTEEPQN 780 SMPDIIIWMI 790 RGEKRLAYAR 800 IPAHQVLYST 810 SGENASGKYC 820 GKTQTIFLKY 830 PQEKNNGPKV 840 PVELRVNIWL 850 GLSAVEKKFN 860 SFAEGTFTVF 870 AEMYENQALM 880 FGKWGTSGLV 890 GRHKFSDVTG 900 KIKLKREFFL 910 PPKGWEWEGE 920 WIVDPERSLL 930 TEADAGHTEF 940 TDEVYQNESR 950 YPGGDWKPAE 960 DTYTDANGDK 970 AASPSELTCP 980 PGWEWEDDAW 990 SYDINRAVDE 1000 KGWEYGITIP 1010 PDHKPKSWVA 1020 AEKMYHTHRR 1030 RRLVRKRKKD 1040 LTQTASSTAR 1050 AMEELQDQEG 1060 WEYASLIGWK 1070 FHWKQRSSDT 1080 FRRRRWRRKM 1090 APSETHGAAA 1100 IFKLEGALGA 1110 DTTEDGDEKS 1120 LEKQKHSATT 1130 VFGANTPIVS 1140 CNFDRVYIYH 1150 LRCYVYQARN 1160 LLALDKDSFS 1170 DPYAHICFLH 1180 RSKTTEIIHS 1190 TLNPTWDQTI 1200 IFDEVEIYGE 1210 PQTVLQNPPK 1220 VIMELFDNDQ 1230 VGKDEFLGRS 1240 IFSPVVKLNS 1250 EMDITPKLLW 1260 HPVMNGDKAC 1270 GDVLVTAELI 1280 LRGKDGSNLP 1290 ILPPQRAPNL 1300 YMVPQGIRPV 1310 VQLTAIEILA 1320 WGLRNMKNFQ 1330 MASITSPSLV 1340 VECGGERVES 1350 VVIKNLKKTP 1360 NFPSSVLFMK 1370 VFLPKEELYM 1380 PPLVIKVIDH 1390 RQFGRKPVVG 1400 QCTIERLDRF 1410 RCDPYAGKED 1420 IVPQLKASLL 1430 SAPPCRDIVI 1440 EMEDTKPLLA 1450 SKLTEKEEEI 1460 VDWWSKFYAS 1470 SGEHEKCGQY 1480 IQKGYSKLKI 1490 YNCELENVAE 1500 FEGLTDFSDT 1510 FKLYRGKSDE 1520 NEDPSVVGEF 1530 KGSFRIYPLP 1540 DDPSVPAPPR 1550 QFRELPDSVP 1560 QECTVRIYIV 1570 RGLELQPQDN 1580 NGLCDPYIKI 1590 TLGKKVIEDR 1600 DHYIPNTLNP 1610 VFGRMYELSC 1620 YLPQEKDLKI 1630 SVYDYDTFTR 1640 DEKVGETIID 1650 LENRFLSRFG 1660 SHCGIPEEYC 1670 VSGVNTWRDQ 1680 LRPTQLLQNV 1690 ARFKGFPQPI 1700 LSEDGSRIRY 1710 GGRDYSLDEF 1720 EANKILHQHL 1730 GAPEERLALH 1740 ILRTQGLVPE 1750 HVETRTLHST 1760 FQPNISQGKL 1770 QMWVDVFPKS 1780 LGPPGPPFNI 1790 TPRKAKKYYL 1800 RVIIWNTKDV 1810 ILDEKSITGE 1820 EMSDIYVKGW 1830 IPGNEENKQK 1840 TDVHYRSLDG 1850 EGNFNWRFVF 1860 PFDYLPAEQL 1870 CIVAKKEHFW 1880 SIDQTEFRIP 1890 PRLIIQIWDN 1900 DKFSLDDYLG 1910 FLELDLRHTI 1920 IPAKSPEKCR 1930 LDMIPDLKAM 1940 NPLKAKTASL 1950 FEQKSMKGWW 1960 PCYAEKDGAR 1970 VMAGKVEMTL 1980 EILNEKEADE 1990 RPAGKGRDEP 2000 NMNPKLDLPN 2010 RPETSFLWFT 2020 NPCKTMKFIV 2030 WRRFKWVIIG 2040 LLFLLILLLF 2050 VAVLLYSLPN 2060 YLSMKIVKPN V

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005901	caveola
Cellular Component	GO:0034451	centriolar satellite
Cellular Component	GO:0031410	cytoplasmic vesicle
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0031902	late endosome membrane
Cellular Component	GO:0005635	nuclear envelope
Cellular Component	GO:0031965	nuclear membrane
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0030672	synaptic vesicle membrane
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0005543	phospholipid binding
Biological Process	GO:0008015	blood circulation
Biological Process	GO:0006936	muscle contraction
Biological Process	GO:0001778	plasma membrane repair
Biological Process	GO:0046928	regulation of neurotransmitter secretion

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.