Search Results

Overview

Uniprot IDQ9NZM3
Protein NameIntersectin-2
Gene NameITSN2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1047 ESFGSASKSGASNKK
1564 AYQARSQKTSGIGRL

Function

Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003)

Protein Sequence

10 MMAQFPTAMN 20 GGPNMWAITS 30 EERTKHDRQF 40 DNLKPSGGYI 50 TGDQARNFFL 60 QSGLPAPVLA 70 EIWALSDLNK 80 DGKMDQQEFS 90 IAMKLIKLKL 100 QGQQLPVVLP 110 PIMKQPPMFS 120 PLISARFGMG 130 SMPNLSIPQP 140 LPPAAPITSL 150 SSATSGTNLP 160 PLMMPTPLVP 170 SVSTSSLPNG 180 TASLIQPLPI 190 PYSSSTLPHG 200 SSYSLMMGGF 210 GGASIQKAQS 220 LIDLGSSSST 230 SSTASLSGNS 240 PKTGTSEWAV 250 PQPTRLKYRQ 260 KFNTLDKSMS 270 GYLSGFQARN 280 ALLQSNLSQT 290 QLATIWTLAD 300 VDGDGQLKAE 310 EFILAMHLTD 320 MAKAGQPLPL 330 TLPPELVPPS 340 FRGGKQIDSI 350 NGTLPSYQKM 360 QEEEPQKKLP 370 VTFEDKRKAN 380 YERGNMELEK 390 RRQALMEQQQ 400 REAERKAQKE 410 KEEWERKQRE 420 LQEQEWKKQL 430 ELEKRLEKQR 440 ELERQREEER 450 RKDIERREAA 460 KQELERQRRL 470 EWERIRRQEL 480 LNQKNREQEE 490 IVRLNSKKKN 500 LHLELEALNG 510 KHQQISGRLQ 520 DVRLKKQTQK 530 TELEVLDKQC 540 DLEIMEIKQL 550 QQELQEYQNK 560 LIYLVPEKQL 570 LNERIKNMQF 580 SNTPDSGVSL 590 LHKKSLEKEE 600 LCQRLKEQLD 610 ALEKETASKL 620 SEMDSFNNQL 630 KCGNMDDSVL 640 QCLLSLLSCL 650 NNLFLLLKEL 660 RETYNTQQLA 670 LEQLYKIKRD 680 KLKEIERKRL 690 ELMQKKKLED 700 EAARKAKQGK 710 ENLWKENLRK 720 EEEEKQKRLQ 730 EEKTQEKIQE 740 EERKAEEKQR 750 KDKDTLKAEE 760 KKRETASVLV 770 NYRALYPFEA 780 RNHDEMSFNS 790 GDIIQVDEKT 800 VGEPGWLYGS 810 FQGNFGWFPC 820 NYVEKMPSSE 830 NEKAVSPKKA 840 LLPPTVSLSA 850 TSTSSEPLSS 860 NQPASVTDYQ 870 NVSFSNLTVN 880 TSWQKKSAFT 890 RTVSPGSVSP 900 IHGQGQVVEN 910 LKAQALCSWT 920 AKKDNHLNFS 930 KHDIITVLEQ 940 QENWWFGEVH 950 GGRGWFPKSY 960 VKIIPGSEVK 970 REEPEALYAA 980 VNKKPTSAAY 990 SVGEEYIALY 1000 PYSSVEPGDL 1010 TFTEGEEILV 1020 TQKDGEWWTG 1030 SIGDRSGIFP 1040 SNYVKPKDQE 1050 SFGSASKSGA 1060 SNKKPEIAQV 1070 TSAYVASGSE 1080 QLSLAPGQLI 1090 LILKKNTSGW 1100 WQGELQARGK 1110 KRQKGWFPAS 1120 HVKLLGPSSE 1130 RATPAFHPVC 1140 QVIAMYDYAA 1150 NNEDELSFSK 1160 GQLINVMNKD 1170 DPDWWQGEIN 1180 GVTGLFPSNY 1190 VKMTTDSDPS 1200 QQWCADLQTL 1210 DTMQPIERKR 1220 QGYIHELIQT 1230 EERYMADLQL 1240 VVEVFQKRMA 1250 ESGFLTEGEM 1260 ALIFVNWKEL 1270 IMSNTKLLKA 1280 LRVRKKTGGE 1290 KMPVQMIGDI 1300 LAAELSHMQA 1310 YIRFCSCQLN 1320 GAALLQQKTD 1330 EDTDFKEFLK 1340 KLASDPRCKG 1350 MPLSSFLLKP 1360 MQRITRYPLL 1370 IRSILENTPE 1380 SHADHSSLKL 1390 ALERAEELCS 1400 QVNEGVREKE 1410 NSDRLEWIQA 1420 HVQCEGLAEQ 1430 LIFNSLTNCL 1440 GPRKLLHSGK 1450 LYKTKSNKEL 1460 HGFLFNDFLL 1470 LTYMVKQFAV 1480 SSGSEKLFSS 1490 KSNAQFKMYK 1500 TPIFLNEVLV 1510 KLPTDPSSDE 1520 PVFHISHIDR 1530 VYTLRTDNIN 1540 ERTAWVQKIK 1550 AASEQYIDTE 1560 KKKREKAYQA 1570 RSQKTSGIGR 1580 LMVHVIEATE 1590 LKACKPNGKS 1600 NPYCEISMGS 1610 QSYTTRTIQD 1620 TLNPKWNFNC 1630 QFFIKDLYQD 1640 VLCLTLFDRD 1650 QFSPDDFLGR 1660 TEIPVAKIRT 1670 EQESKGPMTR 1680 RLLLHEVPTG 1690 EVWVRFDLQL FEQKTLL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Biological Process GO:0030154 cell differentiation
Biological Process GO:0150007 clathrin-dependent synaptic vesicle endocytosis
Biological Process GO:0016197 endosomal transport
Biological Process GO:1903861 positive regulation of dendrite extension
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0097708 intracellular vesicle
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098793 presynapse
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Molecular Function GO:0030674 protein-macromolecule adaptor activity

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.