Search Results

Overview

Uniprot ID	Q9NZM4
Protein Name	BRD4-interacting chromatin-remodeling complex-associated protein
Gene Name	BICRA
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1320	KQEAGLSKVVHNTAL

Function

Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). May play a role in BRD4-mediated gene transcription (PubMed:21555454)

Protein Sequence

10 MDDEDGRCLL 20 DVICDPQALN 30 DFLHGSEKLD 40 SDDLLDNPGE 50 AQSAFYEGPG 60 LHVQEASGNH 70 LNPEPNQPAP 80 SVDLDFLEDD 90 ILGSPATGGG 100 GGGSGGADQP 110 CDILQQSLQE 120 ANITEQTLEA 130 EAELDLGPFQ 140 LPTLQPADGG 150 AGPTGAGGAA 160 AVAAGPQALF 170 PGSTDLLGLQ 180 GPPTVLTHQA 190 LVPPQDVVNK 200 ALSVQPFLQP 210 VGLGNVTLQP 220 IPGLQGLPNG 230 SPGGATAATL 240 GLAPIQVVGQ 250 PVMALNTPTS 260 QLLAKQVPVS 270 GYLASAAGPS 280 EPVTLASAGV 290 SPQGAGLVIQ 300 KNLSAAVATT 310 LNGNSVFGGA 320 GAASAPTGTP 330 SGQPLAVAPG 340 LGSSPLVPAP 350 NVILHRTPTP 360 IQPKPAGVLP 370 PKLYQLTPKP 380 FAPAGATLTI 390 QGEPGALPQQ 400 PKAPQNLTFM 410 AAGKAGQNVV 420 LSGFPAPALQ 430 ANVFKQPPAT 440 TTGAAPPQPP 450 GALSKPMSVH 460 LLNQGSSIVI 470 PAQHMLPGQN 480 QFLLPGAPAV 490 QLPQQLSALP 500 ANVGGQILAA 510 AAPHTGGQLI 520 ANPILTNQNL 530 AGPLSLGPVL 540 APHSGAHSAH 550 ILSAAPIQVG 560 QPALFQMPVS 570 LAAGSLPTQS 580 QPAPAGPAAT 590 TVLQGVTLPP 600 SAVAMLNTPD 610 GLVQPATPAA 620 ATGEAAPVLT 630 VQPAPQAPPA 640 VSTPLPLGLQ 650 QPQAQQPPQA 660 PTPQAAAPPQ 670 ATTPQPSPGL 680 ASSPEKIVLG 690 QPPSATPTAI 700 LTQDSLQMFL 710 PQERSQQPLS 720 AEGPHLSVPA 730 SVIVSAPPPA 740 QDPAPATPVA 750 KGAGLGPQAP 760 DSQASPAPAP 770 QIPAAAPLKG 780 PGPSSSPSLP 790 HQAPLGDSPH 800 LPSPHPTRPP 810 SRPPSRPQSV 820 SRPPSEPPLH 830 PCPPPQAPPT 840 LPGIFVIQNQ 850 LGVPPPASNP 860 APTAPGPPQP 870 PLRPQSQPPE 880 GPLPPAPHLP 890 PSSTSSAVAS 900 SSETSSRLPA 910 PTPSDFQLQF 920 PPSQGPHKSP 930 TPPPTLHLVP 940 EPAAPPPPPP 950 RTFQMVTTPF 960 PALPQPKALL 970 ERFHQVPSGI 980 ILQNKAGGAP 990 AAPQTSTSLG 1000 PLTSPAASVL 1010 VSGQAPSGTP 1020 TAPSHAPAPA 1030 PMAATGLPPL 1040 LPAENKAFAS 1050 NLPTLNVAKA 1060 ASSGPGKPSG 1070 LQYESKLSGL 1080 KKPPTLQPSK 1090 EACFLEHLHK 1100 HQGSVLHPDY 1110 KTAFPSFEDA 1120 LHRLLPYHVY 1130 QGALPSPSDY 1140 HKVDEEFETV 1150 STQLLKRTQA 1160 MLNKYRLLLL 1170 EESRRVSPSA 1180 EMVMIDRMFI 1190 QEEKTTLALD 1200 KQLAKEKPDE 1210 YVSSSRSLGL 1220 PIAASSEGHR 1230 LPGHGPLSSS 1240 APGASTQPPP 1250 HLPTKLVIRH 1260 GGAGGSPSVT 1270 WARASSSLSS 1280 SSSSSSAASS 1290 LDADEDGPMP 1300 SRNRPPIKTY 1310 EARSRIGLKL 1320 KIKQEAGLSK 1330 VVHNTALDPV 1340 HQPPPPPATL 1350 KVAEPPPRPP 1360 PPPPPTGQMN 1370 GTVDHPPPAA 1380 PERKPLGTAP 1390 HCPRLPLRKT 1400 YRENVGGPGA 1410 PEGTPAGRAR 1420 GGSPAPLPAK 1430 VDEATSGLIR 1440 ELAAVEDELY 1450 QRMLKGPPPE 1460 PAASAAQGTG 1470 DPDWEAPGLP 1480 PAKRRKSESP 1490 DVDQASFSSD 1500 SPQDDTLTEH 1510 LQSAIDSILN 1520 LQQAPGRTPA 1530 PSYPHAASAG 1540 TPASPPPLHR 1550 PEAYPPSSHN 1560 GGLGARTLTR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0016514	SWI/SNF complex
Molecular Function	GO:0140537	transcription regulator activator activity
Biological Process	GO:0006338	chromatin remodeling
Biological Process	GO:0045596	negative regulation of cell differentiation
Biological Process	GO:0008284	positive regulation of cell population proliferation
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:1902459	positive regulation of stem cell population maintenance
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.