Search Results
Overview
| Uniprot ID | Q9NZN3 |
|---|---|
| Protein Name | EH domain-containing protein 3 |
| Gene Name | EHD3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 299 | RKLNDLIKRARLAKV |
| 315 | AYIISSLKKEMPSVF |
| 32 | LKKLYKSKLLPLEEH |
Function
ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (PubMed:25686250). In vitro causes tubulation of endocytic membranes (PubMed:24019528). Binding to phosphatidic acid induces its membrane tubulation activity (By similarity). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (PubMed:16251358, PubMed:17233914, PubMed:19139087, PubMed:23781025). Involved in the recycling of internalized D1 dopamine receptor (PubMed:21791287). Plays a role in cardiac protein trafficking probably implicating ANK2 (PubMed:20489164). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction (By similarity). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (By similarity). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PubMed:23781025). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 (PubMed:25686250)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0020018 | ciliary pocket membrane |
| Cellular Component | GO:0035869 | ciliary transition zone |
| Cellular Component | GO:0005929 | cilium |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0030139 | endocytic vesicle |
| Cellular Component | GO:0010008 | endosome membrane |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0055038 | recycling endosome membrane |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003676 | nucleic acid binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Biological Process | GO:0060271 | cilium assembly |
| Biological Process | GO:0034498 | early endosome to Golgi transport |
| Biological Process | GO:0032456 | endocytic recycling |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0090160 | Golgi to lysosome transport |
| Biological Process | GO:0051260 | protein homooligomerization |
| Biological Process | GO:0072659 | protein localization to plasma membrane |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0001881 | receptor recycling |
| Biological Process | GO:1903779 | regulation of cardiac conduction |
| Biological Process | GO:0086036 | regulation of cardiac muscle cell membrane potential |
| Biological Process | GO:0055117 | regulation of cardiac muscle contraction |
| Biological Process | GO:1903358 | regulation of Golgi organization |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.