Search Results

Overview

Uniprot ID	Q9NZN4
Protein Name	EH domain-containing protein 2
Gene Name	EHD2
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
293	PRHAALRKLNDLVKR
32	LKELYRTKLLPLEEH

Function

ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (By similarity). Plays a role in membrane trafficking between the plasma membrane and endosomes (PubMed:17233914). Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane (By similarity). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane (PubMed:25588833)

Protein Sequence

10 MFSWLKRGGA 20 RGQQPEAIRT 30 VTSALKELYR 40 TKLLPLEEHY 50 RFGAFHSPAL 60 EDADFDGKPM 70 VLVAGQYSTG 80 KTSFIQYLLE 90 QEVPGSRVGP 100 EPTTDCFVAV 110 MHGDTEGTVP 120 GNALVVDPDK 130 PFRKLNPFGN 140 TFLNRFMCAQ 150 LPNQVLESIS 160 IIDTPGILSG 170 AKQRVSRGYD 180 FPAVLRWFAE 190 RVDLIILLFD 200 AHKLEISDEF 210 SEAIGALRGH 220 EDKIRVVLNK 230 ADMVETQQLM 240 RVYGALMWAL 250 GKVVGTPEVL 260 RVYIGSFWSQ 270 PLLVPDNRRL 280 FELEEQDLFR 290 DIQGLPRHAA 300 LRKLNDLVKR 310 ARLVRVHAYI 320 ISYLKKEMPS 330 VFGKENKKKQ 340 LILKLPVIFA 350 KIQLEHHISP 360 GDFPDCQKMQ 370 ELLMAHDFTK 380 FHSLKPKLLE 390 ALDEMLTHDI 400 AKLMPLLRQE 410 ELESTEVGVQ 420 GGAFEGTHMG 430 PFVERGPDEA 440 MEDGEEGSDD 450 EAEWVVTKDK 460 SKYDEIFYNL 470 APADGKLSGS 480 KAKTWMVGTK 490 LPNSVLGRIW 500 KLSDVDRDGM 510 LDDEEFALAS 520 HLIEAKLEGH 530 GLPANLPRRL 540 VPPSKRRHKG SAE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005901	caveola
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005769	early endosome
Cellular Component	GO:0030139	endocytic vesicle
Cellular Component	GO:0010008	endosome membrane
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0055038	recycling endosome membrane
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0016787	hydrolase activity
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0003676	nucleic acid binding
Molecular Function	GO:0019904	protein domain specific binding
Molecular Function	GO:0030674	protein-macromolecule adaptor activity
Biological Process	GO:0060271	cilium assembly
Biological Process	GO:0032456	endocytic recycling
Biological Process	GO:0006897	endocytosis
Biological Process	GO:0097320	plasma membrane tubulation
Biological Process	GO:2001137	positive regulation of endocytic recycling
Biological Process	GO:1901741	positive regulation of myoblast fusion
Biological Process	GO:0072659	protein localization to plasma membrane

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.