Search Results

Overview

Uniprot IDQ9NZN5
Protein NameRho guanine nucleotide exchange factor 12
Gene NameARHGEF12
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
577 GRIGFLPKIKQSMKK
579 IGFLPKIKQSMKKDK

Function

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 (PubMed:11094164). May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) (PubMed:11094164). Promotes endothelial cell and actin stress fiber reorientation in response to mechanotransduction (By similarity)

Protein Sequence

10 MSGTQSTITD 20 RFPLKKPIRH 30 GSILNRESPT 40 DKKQKVERIA 50 SHDFDPTDSS 60 SKKTKSSSEE 70 SRSEIYGLVQ 80 RCVIIQKDDN 90 GFGLTVSGDN 100 PVFVQSVKED 110 GAAMRAGVQT 120 GDRIIKVNGT 130 LVTHSNHLEV 140 VKLIKSGSYV 150 ALTVQGRPPG 160 SPQIPLADSE 170 VEPSVIGHMS 180 PIMTSPHSPG 190 ASGNMERITS 200 PVLMGEENNV 210 VHNQKVEILR 220 KMLQKEQERL 230 QLLQEDYNRT 240 PAQRLLKEIQ 250 EAKKHIPQLQ 260 EQLSKATGSA 270 QDGAVVTPSR 280 PLGDTLTVSE 290 AETDPGDVLG 300 RTDCSSGDAS 310 RPSSDNADSP 320 KSGPKERIYL 330 EENPEKSETI 340 QDTDTQSLVG 350 SPSTRIAPHI 360 IGAEDDDFGT 370 EHEQINGQCS 380 CFQSIELLKS 390 RPAHLAVFLH 400 HVVSQFDPAT 410 LLCYLYSDLY 420 KHTNSKETRR 430 IFLEFHQFFL 440 DRSAHLKVSV 450 PDEMSADLEK 460 RRPELIPEDL 470 HRHYIQTMQE 480 RVHPEVQRHL 490 EDFRQKRSMG 500 LTLAESELTK 510 LDAERDKDRL 520 TLEKERTCAE 530 QIVAKIEEVL 540 MTAQAVEEDK 550 SSTMQYVILM 560 YMKHLGVKVK 570 EPRNLEHKRG 580 RIGFLPKIKQ 590 SMKKDKEGEE 600 KGKRRGFPSI 610 LGPPRRPSRH 620 DNSAIGRAME 630 LQKARHPKHL 640 STPSSVSPEP 650 QDSAKLRQSG 660 LANEGTDAGY 670 LPANSMSSVA 680 SGASFSQEGG 690 KENDTGSKQV 700 GETSAPGDTL 710 DGTPRTLNTV 720 FDFPPPPLDQ 730 VQEEECEVER 740 VTEHGTPKPF 750 RKFDSVAFGE 760 SQSEDEQFEN 770 DLETDPPNWQ 780 QLVSREVLLG 790 LKPCEIKRQE 800 VINELFYTER 810 AHVRTLKVLD 820 QVFYQRVSRE 830 GILSPSELRK 840 IFSNLEDILQ 850 LHIGLNEQMK 860 AVRKRNETSV 870 IDQIGEDLLT 880 WFSGPGEEKL 890 KHAAATFCSN 900 QPFALEMIKS 910 RQKKDSRFQT 920 FVQDAESNPL 930 CRRLQLKDII 940 PTQMQRLTKY 950 PLLLDNIAKY 960 TEWPTEREKV 970 KKAADHCRQI 980 LNYVNQAVKE 990 AENKQRLEDY 1000 QRRLDTSSLK 1010 LSEYPNVEEL 1020 RNLDLTKRKM 1030 IHEGPLVWKV 1040 NRDKTIDLYT 1050 LLLEDILVLL 1060 QKQDDRLVLR 1070 CHSKILASTA 1080 DSKHTFSPVI 1090 KLSTVLVRQV 1100 ATDNKALFVI 1110 SMSDNGAQIY 1120 ELVAQTVSEK 1130 TVWQDLICRM 1140 AASVKEQSTK 1150 PIPLPQSTPG 1160 EGDNDEEDPS 1170 KLKEEQHGIS 1180 VTGLQSPDRD 1190 LGLESTLISS 1200 KPQSHSLSTS 1210 GKSEVRDLFV 1220 AERQFAKEQH 1230 TDGTLKEVGE 1240 DYQIAIPDSH 1250 LPVSEERWAL 1260 DALRNLGLLK 1270 QLLVQQLGLT 1280 EKSVQEDWQH 1290 FPRYRTASQG 1300 PQTDSVIQNS 1310 ENIKAYHSGE 1320 GHMPFRTGTG 1330 DIATCYSPRT 1340 STESFAPRDS 1350 VGLAPQDSQA 1360 SNILVMDHMI 1370 MTPEMPTMEP 1380 EGGLDDSGEH 1390 FFDAREAHSD 1400 ENPSEGDGAV 1410 NKEEKDVNLR 1420 ISGNYLILDG 1430 YDPVQESSTD 1440 EEVASSLTLQ 1450 PMTGIPAVES 1460 THQQQHSPQN 1470 THSDGAISPF 1480 TPEFLVQQRW 1490 GAMEYSCFEI 1500 QSPSSCADSQ 1510 SQIMEYIHKI 1520 EADLEHLKKV 1530 EESYTILCQR 1540 LAGSALTDKH SDKS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016020 membrane
Molecular Function GO:0001664 G protein-coupled receptor binding
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process GO:0007015 actin filament organization
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0051056 regulation of small GTPase mediated signal transduction
Biological Process GO:0007266 Rho protein signal transduction
Biological Process GO:0160221 Rho-activating G protein-coupled receptor signaling pathway

Reference

PMID: N/A