Overview
| Uniprot ID | Q9NZN8 |
|---|
| Protein Name | CCR4-NOT transcription complex subunit 2 |
|---|
| Gene Name | CNOT2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 178 |
PSIICMPKQQPSRQP |
| 333 |
QNNNQQKKGIQVLPD |
Function
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity
Protein Sequence
10
MVRTDGHTLS
20
EKRNYQVTNS
30
MFGASRKKFV
40
EGVDSDYHDE
50
NMYYSQSSMF
60
PHRSEKDMLA
70
SPSTSGQLSQ
80
FGASLYGQQS
90
ALGLPMRGMS
100
NNTPQLNRSL
110
SQGTQLPSHV
120
TPTTGVPTMS
130
LHTPPSPSRG
140
ILPMNPRNMM
150
NHSQVGQGIG
160
IPSRTNSMSS
170
SGLGSPNRSS
180
PSIICMPKQQ
190
PSRQPFTVNS
200
MSGFGMNRNQ
210
AFGMNNSLSS
220
NIFNGTDGSE
230
NVTGLDLSDF
240
PALADRNRRE
250
GSGNPTPLIN
260
PLAGRAPYVG
270
MVTKPANEQS
280
QDFSIHNEDF
290
PALPGSSYKD
300
PTSSNDDSKS
310
NLNTSGKTTS
320
STDGPKFPGD
330
KSSTTQNNNQ
340
QKKGIQVLPD
350
GRVTNIPQGM
360
VTDQFGMIGL
370
LTFIRAAETD
380
PGMVHLALGS
390
DLTTLGLNLN
400
SPENLYPKFA
410
SPWASSPCRP
420
QDIDFHVPSE
430
YLTNIHIRDK
440
LAAIKLGRYG
450
EDLLFYLYYM
460
NGGDVLQLLA
470
AVELFNRDWR
480
YHKEERVWIT
490
RAPGMEPTMK
500
TNTYERGTYY
510
FFDCLNWRKV
520
AKEFHLEYDK
530
LEERPHLPST
540
FNYNPAQQAF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030014 |
CCR4-NOT complex |
| Cellular Component |
GO:0030015 |
CCR4-NOT core complex |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0000932 |
P-body |
| Molecular Function |
GO:0003712 |
transcription coregulator activity |
| Molecular Function |
GO:0001222 |
transcription corepressor binding |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0033147 |
negative regulation of intracellular estrogen receptor signaling pathway |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0000289 |
nuclear-transcribed mRNA poly(A) tail shortening |
| Biological Process |
GO:0010606 |
positive regulation of cytoplasmic mRNA processing body assembly |
| Biological Process |
GO:2000036 |
regulation of stem cell population maintenance |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0006417 |
regulation of translation |
| Biological Process |
GO:0031047 |
regulatory ncRNA-mediated gene silencing |
| Biological Process |
GO:0001829 |
trophectodermal cell differentiation |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.