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Overview

Uniprot IDQ9NZT2
Protein NameOpioid growth factor receptor
Gene NameOGFR
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
336 TCGPEHSKGGGRVDE
460 DKVRKRRKVDEGAGD
492 PAPSGHPKAGHSENG

Function

Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation

Protein Sequence

10 MDDPDCDSTW 20 EEDEEDAEDA 30 EDEDCEDGEA 40 AGARDADAGD 50 EDEESEEPRA 60 ARPSSFQSRM 70 TGSRNWRATR 80 DMCRYRHNYP 90 DLVERDCNGD 100 TPNLSFYRNE 110 IRFLPNGCFI 120 EDILQNWTDN 130 YDLLEDNHSY 140 IQWLFPLREP 150 GVNWHAKPLT 160 LREVEVFKSS 170 QEIQERLVRA 180 YELMLGFYGI 190 RLEDRGTGTV 200 GRAQNYQKRF 210 QNLNWRSHNN 220 LRITRILKSL 230 GELGLEHFQA 240 PLVRFFLEET 250 LVRRELPGVR 260 QSALDYFMFA 270 VRCRHQRRQL 280 VHFAWEHFRP 290 RCKFVWGPQD 300 KLRRFKPSSL 310 PHPLEGSRKV 320 EEEGSPGDPD 330 HEASTQGRTC 340 GPEHSKGGGR 350 VDEGPQPRSV 360 EPQDAGPLER 370 SQGDEAGGHG 380 EDRPEPLSPK 390 ESKKRKLELS 400 RREQPPTEPG 410 PQSASEVEKI 420 ALNLEGCALS 430 QGSLRTGTQE 440 VGGQDPGEAV 450 QPCRQPLGAR 460 VADKVRKRRK 470 VDEGAGDSAA 480 VASGGAQTLA 490 LAGSPAPSGH 500 PKAGHSENGV 510 EEDTEGRTGP 520 KEGTPGSPSE 530 TPGPSPAGPA 540 GDEPAESPSE 550 TPGPRPAGPA 560 GDEPAESPSE 570 TPGPRPAGPA 580 GDEPAESPSE 590 TPGPSPAGPT 600 RDEPAESPSE 610 TPGPRPAGPA 620 GDEPAESPSE 630 TPGPRPAGPA 640 GDEPAESPSE 650 TPGPSPAGPT 660 RDEPAKAGEA 670 AELQDAEVES SAKSGKP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Molecular Function GO:0140625 opioid growth factor receptor activity
Biological Process GO:0001558 regulation of cell growth

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.