Search Results

Overview

Uniprot ID	Q9NZU5
Protein Name	LIM and cysteine-rich domains protein 1
Gene Name	LMCD1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
6	**MAKVAKDLNPGVK
86	STLTARVKGGDGIRI

Function

Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway

Protein Sequence

10 MAKVAKDLNP 20 GVKKMSLGQL 30 QSARGVACLG 40 CKGTCSGFEP 50 HSWRKICKSC 60 KCSQEDHCLT 70 SDLEDDRKIG 80 RLLMDSKYST 90 LTARVKGGDG 100 IRIYKRNRMI 110 MTNPIATGKD 120 PTFDTITYEW 130 APPGVTQKLG 140 LQYMELIPKE 150 KQPVTGTEGA 160 FYRRRQLMHQ 170 LPIYDQDPSR 180 CRGLLENELK 190 LMEEFVKQYK 200 SEALGVGEVA 210 LPGQGGLPKE 220 EGKQQEKPEG 230 AETTAATTNG 240 SLSDPSKEVE 250 YVCELCKGAA 260 PPDSPVVYSD 270 RAGYNKQWHP 280 TCFVCAKCSE 290 PLVDLIYFWK 300 DGAPWCGRHY 310 CESLRPRCSG 320 CDEIIFAEDY 330 QRVEDLAWHR 340 KHFVCEGCEQ 350 LLSGRAYIVT 360 KGQLLCPTCS KSKRS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003714	transcription corepressor activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade
Biological Process	GO:0010611	regulation of cardiac muscle hypertrophy

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.