Search Results
Overview
| Uniprot ID | Q9NZZ3 |
|---|---|
| Protein Name | Charged multivesicular body protein 5 |
| Gene Name | CHMP5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 11 | LFGKAKPKAPPPSLT |
| 110 | KTTVDAMKLGVKEMK |
| 7 | *MNRLFGKAKPKAPP |
| 9 | NRLFGKAKPKAPPPS |
Function
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses) (PubMed:14519844). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release (PubMed:14519844)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0006900 | vesicle budding from membrane |
| Cellular Component | GO:1904930 | amphisome membrane |
| Cellular Component | GO:0000421 | autophagosome membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0000815 | ESCRT III complex |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0005828 | kinetochore microtubule |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0005771 | multivesicular body |
| Cellular Component | GO:0032585 | multivesicular body membrane |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0005643 | nuclear pore |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0045296 | cadherin binding |
| Biological Process | GO:0097352 | autophagosome maturation |
| Biological Process | GO:0006914 | autophagy |
| Biological Process | GO:0071222 | cellular response to lipopolysaccharide |
| Biological Process | GO:0071225 | cellular response to muramyl dipeptide |
| Biological Process | GO:1904903 | ESCRT III complex disassembly |
| Biological Process | GO:1902774 | late endosome to lysosome transport |
| Biological Process | GO:0032511 | late endosome to vacuole transport via multivesicular body sorting pathway |
| Biological Process | GO:0090148 | membrane fission |
| Biological Process | GO:0061952 | midbody abscission |
| Biological Process | GO:0007080 | mitotic metaphase chromosome alignment |
| Biological Process | GO:0036258 | multivesicular body assembly |
| Biological Process | GO:0071985 | multivesicular body sorting pathway |
| Biological Process | GO:0061763 | multivesicular body-lysosome fusion |
| Biological Process | GO:0031468 | nuclear membrane reassembly |
| Biological Process | GO:0006997 | nucleus organization |
| Biological Process | GO:0001778 | plasma membrane repair |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0010824 | regulation of centrosome duplication |
| Biological Process | GO:1901673 | regulation of mitotic spindle assembly |
| Biological Process | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway |
| Biological Process | GO:0051469 | vesicle fusion with vacuole |
| Biological Process | GO:0046755 | viral budding |
| Biological Process | GO:0046761 | viral budding from plasma membrane |
| Biological Process | GO:0039702 | viral budding via host ESCRT complex |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.