Search Results
Overview
| Uniprot ID | Q9P000 |
|---|---|
| Protein Name | COMM domain-containing protein 9 |
| Gene Name | COMMD9 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 163 | DPSLCGDKPSISAVT |
Function
Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203)
Protein Sequence
10
MAALTAEHFA
20
ALQSLLKASS
30
KDVVRQLCQE
40
SFSSSALGLK
50
KLLDVTCSSL
60
SVTQEEAEEL
70
LQALHRLTRL
80
VAFRDLSSAE
90
AILALFPENF
100
HQNLKNLLTK
110
IILEHVSTWR
120
TEAQANQISL
130
PRLVDLDWRV
140
DIKTSSDSIS
150
RMAVPTCLLQ
160
MKIQEDPSLC
170
GDKPSISAVT
180
VELSKETLDT
190
MLDGLGRIRD
QLSAVASK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0010008 | endosome membrane |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:1904813 | ficolin-1-rich granule lumen |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0034774 | secretory granule lumen |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0032456 | endocytic recycling |
| Biological Process | GO:0006814 | sodium ion transport |
Reference
PMID: N/A