Search Results

Overview

Uniprot IDQ9P013
Protein NameSpliceosome-associated protein CWC15 homolog
Gene NameCWC15
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
18 PARGGRGKGEGDLSQ
199 VVFKNCAKGVDDQKK
28 GDLSQLSKQYSSRDL
40 RDLPSHTKIKYRQTT
42 LPSHTKIKYRQTTQD
91 TTSSSVSKKPRLDQI

Function

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28076346, PubMed:28502770). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)

Protein Sequence

10 MTTAARPTFE 20 PARGGRGKGE 30 GDLSQLSKQY 40 SSRDLPSHTK 50 IKYRQTTQDA 60 PEEVRNRDFR 70 RELEERERAA 80 AREKNRDRPT 90 REHTTSSSVS 100 KKPRLDQIPA 110 ANLDADDPLT 120 DEEDEDFEEE 130 SDDDDTAALL 140 AELEKIKKER 150 AEEQARKEQE 160 QKAEEERIRM 170 ENILSGNPLL 180 NLTGPSQPQA 190 NFKVKRRWDD 200 DVVFKNCAKG 210 VDDQKKDKRF 220 VNDTLRSEFH KKFMEKYIK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071013 catalytic step 2 spliceosome
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005681 spliceosomal complex
Cellular Component GO:0071007 U2-type catalytic step 2 spliceosome
Molecular Function GO:0003723 RNA binding
Biological Process GO:0045292 mRNA cis splicing, via spliceosome
Biological Process GO:0000398 mRNA splicing, via spliceosome

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[5] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[6] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.