Search Results

Overview

Uniprot IDQ9P016
Protein NameThymocyte nuclear protein 1
Gene NameTHYN1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
16 AGTSGSDKGLSGKRT
21 SDKGLSGKRTKTENS
24 GLSGKRTKTENSGEA
42 VEDSNPQKTSATKNC
47 PQKTSATKNCLKNLS
51 SATKNCLKNLSSHWL

Function

Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC

Protein Sequence

10 MSRPRKRLAG 20 TSGSDKGLSG 30 KRTKTENSGE 40 ALAKVEDSNP 50 QKTSATKNCL 60 KNLSSHWLMK 70 SEPESRLEKG 80 VDVKFSIEDL 90 KAQPKQTTCW 100 DGVRNYQARN 110 FLRAMKLGEE 120 AFFYHSNCKE 130 PGIAGLMKIV 140 KEAYPDHTQF 150 EKNNPHYDPS 160 SKEDNPKWSM 170 VDVQFVRMMK 180 RFIPLAELKS 190 YHQAHKATGG 200 PLKNMVLFTR 210 QRLSIQPLTQ 220 EEFDFVLSLE EKEPS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0001650 fibrillar center
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.