Search Results
Overview
| Uniprot ID | Q9P021 |
|---|---|
| Protein Name | Cysteine-rich PDZ-binding protein |
| Gene Name | CRIPT |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 20 | VITPDTWKDGARNTT |
| 38 | GRKLNENKALTSKKA |
| 54 | FDPYGKNKFSTCRIC |
| 94 | GKKVLDTKNYKQTSV |
Function
As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0043198 | dendritic shaft |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0099092 | postsynaptic density, intracellular component |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0030165 | PDZ domain binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0097110 | scaffold protein binding |
| Biological Process | GO:0031122 | cytoplasmic microtubule organization |
| Biological Process | GO:0000398 | mRNA splicing, via spliceosome |
| Biological Process | GO:0035372 | protein localization to microtubule |
| Biological Process | GO:0099151 | regulation of postsynaptic density assembly |
| Biological Process | GO:1902897 | regulation of postsynaptic density protein 95 clustering |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.