Overview
| Uniprot ID | Q9P0J0 |
|---|
| Protein Name | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 |
|---|
| Gene Name | NDUFA13 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 7 |
*MAASKVKQDMPPPG |
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371). Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091)
Protein Sequence
10
MAASKVKQDM
20
PPPGGYGPID
30
YKRNLPRRGL
40
SGYSMLAIGI
50
GTLIYGHWSI
60
MKWNRERRRL
70
QIEDFEARIA
80
LLPLLQAETD
90
RRTLQMLREN
100
LEEEAIIMKD
110
VPDWKVGESV
120
FHTTRWVPPL
130
IGELYGLRTT
140
EEALHASHGF
MWYT
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0061133 |
endopeptidase activator activity |
| Biological Process |
GO:0009060 |
aerobic respiration |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0035458 |
cellular response to interferon-beta |
| Biological Process |
GO:0071300 |
cellular response to retinoic acid |
| Biological Process |
GO:0032981 |
mitochondrial respiratory chain complex I assembly |
| Biological Process |
GO:0045892 |
negative regulation of DNA-templated transcription |
| Biological Process |
GO:1900119 |
positive regulation of execution phase of apoptosis |
| Biological Process |
GO:0045732 |
positive regulation of protein catabolic process |
| Biological Process |
GO:0045039 |
protein insertion into mitochondrial inner membrane |
| Biological Process |
GO:0042776 |
proton motive force-driven mitochondrial ATP synthesis |
| Biological Process |
GO:0022904 |
respiratory electron transport chain |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0031966 |
mitochondrial membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0098803 |
respiratory chain complex |
| Cellular Component |
GO:0045271 |
respiratory chain complex I |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.