Overview
| Uniprot ID | Q9P0U3 |
|---|
| Protein Name | Sentrin-specific protease 1 |
|---|
| Gene Name | SENP1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 111 |
SSSSSLQKSRNSRSL |
| 409 |
VVQETQKKGHKLTDS |
Function
Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:15487983, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (PubMed:15487983). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:15199155, PubMed:16253240, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). Deconjugates SUMO1 from HIPK2 (PubMed:16253240). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (PubMed:15199155, PubMed:21829689). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (PubMed:23160374). Deconjugates SUMO2 from MTA1 (PubMed:21965678). Inhibits N(6)-methyladenosine (m6A) RNA methylation by mediating SUMO1 deconjugation from METTL3 and ALKBH5: METTL3 inhibits the m6A RNA methyltransferase activity, while ALKBH5 desumoylation promotes m6A demethylation (PubMed:29506078, PubMed:34048572, PubMed:37257451). Desumoylates CCAR2 which decreases its interaction with SIRT1 (PubMed:25406032). Deconjugates SUMO1 from GPS2 (PubMed:24943844)
Protein Sequence
10
MDDIADRMRM
20
DAGEVTLVNH
30
NSVFKTHLLP
40
QTGFPEDQLS
50
LSDQQILSSR
60
QGHLDRSFTC
70
STRSAAYNPS
80
YYSDNPSSDS
90
FLGSGDLRTF
100
GQSANGQWRN
110
STPSSSSSLQ
120
KSRNSRSLYL
130
ETRKTSSGLS
140
NSFAGKSNHH
150
CHVSAYEKSF
160
PIKPVPSPSW
170
SGSCRRSLLS
180
PKKTQRRHVS
190
TAEETVQEEE
200
REIYRQLLQM
210
VTGKQFTIAK
220
PTTHFPLHLS
230
RCLSSSKNTL
240
KDSLFKNGNS
250
CASQIIGSDT
260
SSSGSASILT
270
NQEQLSHSVY
280
SLSSYTPDVA
290
FGSKDSGTLH
300
HPHHHHSVPH
310
QPDNLAASNT
320
QSEGSDSVIL
330
LKVKDSQTPT
340
PSSTFFQAEL
350
WIKELTSVYD
360
SRARERLRQI
370
EEQKALALQL
380
QNQRLQEREH
390
SVHDSVELHL
400
RVPLEKEIPV
410
TVVQETQKKG
420
HKLTDSEDEF
430
PEITEEMEKE
440
IKNVFRNGNQ
450
DEVLSEAFRL
460
TITRKDIQTL
470
NHLNWLNDEI
480
INFYMNMLME
490
RSKEKGLPSV
500
HAFNTFFFTK
510
LKTAGYQAVK
520
RWTKKVDVFS
530
VDILLVPIHL
540
GVHWCLAVVD
550
FRKKNITYYD
560
SMGGINNEAC
570
RILLQYLKQE
580
SIDKKRKEFD
590
TNGWQLFSKK
600
SQEIPQQMNG
610
SDCGMFACKY
620
ADCITKDRPI
630
NFTQQHMPYF
640
RKRMVWEILH
RKLL
Gene Ontology
| Classification |
GO ID |
Description |
| Molecular Function |
GO:0016929 |
deSUMOylase activity |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0099524 |
postsynaptic cytosol |
| Cellular Component |
GO:0099523 |
presynaptic cytosol |
| Molecular Function |
GO:0004175 |
endopeptidase activity |
| Molecular Function |
GO:0070139 |
SUMO-specific endopeptidase activity |
| Biological Process |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0016926 |
protein desumoylation |
| Biological Process |
GO:0016925 |
protein sumoylation |
| Biological Process |
GO:0006508 |
proteolysis |
| Biological Process |
GO:0043488 |
regulation of mRNA stability |
Reference
PMID: N/A