Search Results
Overview
| Uniprot ID | Q9P0U4 |
|---|---|
| Protein Name | CXXC-type zinc finger protein 1 |
| Gene Name | CXXC1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 250 | QQPQPSQKLGRIRED |
Function
Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG
Protein Sequence
10
MEGDGSDPEP
20
PDAGEDSKSE
30
NGENAPIYCI
40
CRKPDINCFM
50
IGCDNCNEWF
60
HGDCIRITEK
70
MAKAIREWYC
80
RECREKDPKL
90
EIRYRHKKSR
100
ERDGNERDSS
110
EPRDEGGGRK
120
RPVPDPDLQR
130
RAGSGTGVGA
140
MLARGSASPH
150
KSSPQPLVAT
160
PSQHHQQQQQ
170
QIKRSARMCG
180
ECEACRRTED
190
CGHCDFCRDM
200
KKFGGPNKIR
210
QKCRLRQCQL
220
RARESYKYFP
230
SSLSPVTPSE
240
SLPRPRRPLP
250
TQQQPQPSQK
260
LGRIREDEGA
270
VASSTVKEPP
280
EATATPEPLS
290
DEDLPLDPDL
300
YQDFCAGAFD
310
DHGLPWMSDT
320
EESPFLDPAL
330
RKRAVKVKHV
340
KRREKKSEKK
350
KEERYKRHRQ
360
KQKHKDKWKH
370
PERADAKDPA
380
SLPQCLGPGC
390
VRPAQPSSKY
400
CSDDCGMKLA
410
ANRIYEILPQ
420
RIQQWQQSPC
430
IAEEHGKKLL
440
ERIRREQQSA
450
RTRLQEMERR
460
FHELEAIILR
470
AKQQAVREDE
480
ESNEGDSDDT
490
DLQIFCVSCG
500
HPINPRVALR
510
HMERCYAKYE
520
SQTSFGSMYP
530
TRIEGATRLF
540
CDVYNPQSKT
550
YCKRLQVLCP
560
EHSRDPKVPA
570
DEVCGCPLVR
580
DVFELTGDFC
590
RLPKRQCNRH
600
YCWEKLRRAE
610
VDLERVRVWY
620
KLDELFEQER
630
NVRTAMTNRA
640
GLLALMLHQT
650
IQHDPLTTDL
RSSADR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035097 | histone methyltransferase complex |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048188 | Set1C/COMPASS complex |
| Molecular Function | GO:0000987 | cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0140002 | histone H3K4me3 reader activity |
| Molecular Function | GO:0045322 | unmethylated CpG binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
Reference
[1] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.