Search Results

Overview

Uniprot ID	Q9P0W2
Protein Name	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
Gene Name	HMG20B
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
110	MLGAEWSKLQPTEKQ
144	YQQSEAYKMCTEKIQ
149	AYKMCTEKIQEKKIK
18	AAAPAGGKAPGQHGG
31	GGFVVTVKQERGEGP
52	SHEEEPVKKRGWPKG
6	**MSHGPKQPGAAAA
64	PKGKKRKKILPNGPK

Function

Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters

Protein Sequence

10 MSHGPKQPGA 20 AAAPAGGKAP 30 GQHGGFVVTV 40 KQERGEGPRA 50 GEKGSHEEEP 60 VKKRGWPKGK 70 KRKKILPNGP 80 KAPVTGYVRF 90 LNERREQIRT 100 RHPDLPFPEI 110 TKMLGAEWSK 120 LQPTEKQRYL 130 DEAEREKQQY 140 MKELRAYQQS 150 EAYKMCTEKI 160 QEKKIKKEDS 170 SSGLMNTLLN 180 GHKGGDCDGF 190 STFDVPIFTE 200 EFLDQNKARE 210 AELRRLRKMN 220 VAFEEQNAVL 230 QRHTQSMSSA 240 RERLEQELAL 250 EERRTLALQQ 260 QLQAVRQALT 270 ASFASLPVPG 280 TGETPTLGTL 290 DFYMARLHGA 300 IERDPAQHEK 310 LIVRIKEILA QVASEHL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005694	chromosome
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003677	DNA binding
Biological Process	GO:0006325	chromatin organization
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0010468	regulation of gene expression

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.