Search Results
Overview
| Uniprot ID | Q9P0Z9 |
|---|---|
| Protein Name | Peroxisomal sarcosine oxidase |
| Gene Name | PIPOX |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 104 | MKENQELKTIQANLS |
| 336 | FILDRHPKYDNIVIG |
| 387 | SRFPSLGKAHL**** |
| 57 | GQSRIIRKAYLEDFY |
| 98 | GLLLLGMKENQELKT |
Function
Metabolizes sarcosine and L-pipecolic acid
Protein Sequence
10
MAAQKDLWDA
20
IVIGAGIQGC
30
FTAYHLAKHR
40
KRILLLEQFF
50
LPHSRGSSHG
60
QSRIIRKAYL
70
EDFYTRMMHE
80
CYQIWAQLEH
90
EAGTQLHRQT
100
GLLLLGMKEN
110
QELKTIQANL
120
SRQRVEHQCL
130
SSEELKQRFP
140
NIRLPRGEVG
150
LLDNSGGVIY
160
AYKALRALQD
170
AIRQLGGIVR
180
DGEKVVEINP
190
GLLVTVKTTS
200
RSYQAKSLVI
210
TAGPWTNQLL
220
RPLGIEMPLQ
230
TLRINVCYWR
240
EMVPGSYGVS
250
QAFPCFLWLG
260
LCPHHIYGLP
270
TGEYPGLMKV
280
SYHHGNHADP
290
EERDCPTART
300
DIGDVQILSS
310
FVRDHLPDLK
320
PEPAVIESCM
330
YTNTPDEQFI
340
LDRHPKYDNI
350
VIGAGFSGHG
360
FKLAPVVGKI
370
LYELSMKLTP
380
SYDLAPFRIS
390
RFPSLGKAHL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005782 | peroxisomal matrix |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0050660 | flavin adenine dinucleotide binding |
| Molecular Function | GO:0050031 | L-pipecolate oxidase activity |
| Molecular Function | GO:0008115 | sarcosine oxidase activity |
| Biological Process | GO:0033514 | L-lysine catabolic process to acetyl-CoA via L-pipecolate |
| Biological Process | GO:0006554 | lysine catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.