Overview
| Uniprot ID | Q9P126 |
|---|
| Protein Name | C-type lectin domain family 1 member B |
|---|
| Gene Name | CLEC1B |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 219 |
HYLMCERKAGMTKVD |
| 224 |
ERKAGMTKVDQLP** |
Function
C-type lectin-like receptor that serves as a platelet receptor for the lymphatic endothelial marker PDPN (PubMed:18215137). Plays an essential role in blood/lymphatic vessel separation and thrombus formation through homophilic association (PubMed:22556408). Acts as a negative regulator of lymphatic endothelial cell behavior by inhibiting proliferation, migration, and tube formation (PubMed:22556408). Upon ligand binding, triggers a signaling cascade via sequential activation of SRC and SYK tyrosine kinases, leading to activation of PLCG2 (PubMed:18955485). Through this pathway, mediates platelet adhesion, aggregation, and secretion in response to PDPN-expressing cells. During embryonic development, plays a central role in cerebrovascular formation and blood/lymphatic vessel separation. Interacts with PDPN on neuroepithelial cells to promote platelet activation, thereby ensuring maturation and integrity of cerebrovascular structures and preventing hemorrhage
Protein Sequence
10
MQDEDGYITL
20
NIKTRKPALI
30
SVGSASSSWW
40
RVMALILLIL
50
CVGMVVGLVA
60
LGIWSVMQRN
70
YLQGENENRT
80
GTLQQLAKRF
90
CQYVVKQSEL
100
KGTFKGHKCS
110
PCDTNWRYYG
120
DSCYGFFRHN
130
LTWEESKQYC
140
TDMNATLLKI
150
DNRNIVEYIK
160
ARTHLIRWVG
170
LSRQKSNEVW
180
KWEDGSVISE
190
NMFEFLEDGK
200
GNMNCAYFHN
210
GKMHPTFCEN
220
KHYLMCERKA
GMTKVDQLP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0030246 |
carbohydrate binding |
| Molecular Function |
GO:0004888 |
transmembrane signaling receptor activity |
| Biological Process |
GO:0007166 |
cell surface receptor signaling pathway |
| Biological Process |
GO:0006952 |
defense response |
| Biological Process |
GO:0030220 |
platelet formation |
| Biological Process |
GO:0007165 |
signal transduction |
Reference
[1] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.