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Overview

Uniprot IDQ9P203
Protein NameBTB/POZ domain-containing protein 7
Gene NameBTBD7
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
322 LDESIIPKKYATVIL
538 EVLSDAMKRGLISTP

Function

Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell-scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression (By similarity)

Protein Sequence

10 MGANASNYPH 20 SCSPRVGGNS 30 QAQQTFIGTS 40 SYSQQGYGCE 50 SKLYSLDHGH 60 EKPQDKKKRT 70 SGLATLKKKF 80 IKRRKSNRSA 90 DHAKQMRELL 100 SGWDVRDVNA 110 LVEEYEGTSA 120 LKELSLQASL 130 ARPEARTLQK 140 DMADLYEYKY 150 CTDVDLIFQE 160 TCFPVHRAIL 170 AARCPFFKTL 180 LSSSPEYGAE 190 IIMDINTAGI 200 DMPMFSALLH 210 YLYTGEFGME 220 DSRFQNVDIL 230 VQLSEEFGTP 240 NSLDVDMRGL 250 FDYMCYYDVV 260 LSFSSDSELV 270 EAFGGNQNCL 280 DEELKAHKAV 290 ISARSPFFRN 300 LLQRRIRTGE 310 EITDRTLRTP 320 TRIILDESII 330 PKKYATVILH 340 CMYTDVVDLS 350 VLHCSPSVGS 360 LSEVQALVAG 370 KPNMTRAEEA 380 MELYHIALFL 390 EFNMLAQGCE 400 DIIAESISLD 410 TLIAILKWSS 420 HPYGSKWVHR 430 QALHFLCEEF 440 SQVMTSDVFY 450 ELSKDHLLTA 460 IQSDYLQASE 470 QDILKYLIKW 480 GEHQLMKRIA 490 DREPNLLSGT 500 AHSVNKRGVK 510 RRDLDMEELR 520 EILSSLLPFV 530 RIEHILPINS 540 EVLSDAMKRG 550 LISTPPSDML 560 PTTEGGKSNA 570 WLRQKNAGIY 580 VRPRLFSPYV 590 EEAKSVLDEM 600 MVEQTDLVRL 610 RMVRMSNVPD 620 TLYMVNNAVP 630 QCCHMISHQQ 640 ISSNQSSPPS 650 VVANEIPVPR 660 LLIMKDMVRR 670 LQELRHTEQV 680 QRAYALNCGE 690 GATVSYEIQI 700 RVLREFGLAD 710 AAAELLQNPH 720 KFFPDERFGD 730 ESPLLTMRQP 740 GRCRVNSTPP 750 AETMFTDLDS 760 FVAFHPPLPP 770 PPPPYHPPAT 780 PIHNQLKAGW 790 KQRPPSQHPS 800 RSFSYPCNHS 810 LFHSRTAPKA 820 GPPPVYLPSV 830 KAAPPDCTST 840 AGLGRQTVAA 850 AAATTTSTAT 860 AAAAAASEKQ 870 VRTQPVLNDL 880 MPDIAVGVST 890 LSLKDRRLPE 900 LAVDTELSQS 910 VSEAGPGPPQ 920 HLSCIPQRHT 930 HTSRKKHTLE 940 QKTDTRENPQ 950 EYPDFYDFSN 960 AACRPSTPAL 970 SRRTPSPSQG 980 GYFGPDLYSH 990 NKASPSGLKS 1000 AYLPGQTSPK 1010 KQEEARREYP 1020 LSPDGHLHRQ 1030 KNEPIHLDVV 1040 EQPPQRSDFP 1050 LAAPENASTG 1060 PAHVRGRTAV 1070 ETDLTFGLTP 1080 NRPSLSACSS 1090 EAPEERSGRR 1100 LADSESLGHG 1110 AQRNTDLERE 1120 DSISRGRRSP 1130 SKPDFLYKKS AL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Biological Process GO:0061138 morphogenesis of a branching epithelium
Biological Process GO:0060693 regulation of branching involved in salivary gland morphogenesis

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.