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Overview

Uniprot ID	Q9P241
Protein Name	Phospholipid-transporting ATPase VD
Gene Name	ATP10D
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
885	SAMRLENKLTLLGAT

Function

Catalytic component of a P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of glucosylceramide (GlcCer) from the outer to the inner leaflet of the plasma membrane

Protein Sequence

10 MTEALQWARY 20 HWRRLIRGAT 30 RDDDSGPYNY 40 SSLLACGRKS 50 SQTPKLSGRH 60 RIVVPHIQPF 70 KDEYEKFSGA 80 YVNNRIRTTK 90 YTLLNFVPRN 100 LFEQFHRAAN 110 LYFLFLVVLN 120 WVPLVEAFQK 130 EITMLPLVVV 140 LTIIAIKDGL 150 EDYRKYKIDK 160 QINNLITKVY 170 SRKEKKYIDR 180 CWKDVTVGDF 190 IRLSCNEVIP 200 ADMVLLFSTD 210 PDGICHIETS 220 GLDGESNLKQ 230 RQVVRGYAEQ 240 DSEVDPEKFS 250 SRIECESPNN 260 DLSRFRGFLE 270 HSNKERVGLS 280 KENLLLRGCT 290 IRNTEAVVGI 300 VVYAGHETKA 310 MLNNSGPRYK 320 RSKLERRANT 330 DVLWCVMLLV 340 IMCLTGAVGH 350 GIWLSRYEKM 360 HFFNVPEPDG 370 HIISPLLAGF 380 YMFWTMIILL 390 QVLIPISLYV 400 SIEIVKLGQI 410 YFIQSDVDFY 420 NEKMDSIVQC 430 RALNIAEDLG 440 QIQYLFSDKT 450 GTLTENKMVF 460 RRCSVAGFDY 470 CHEENARRLE 480 SYQEAVSEDE 490 DFIDTVSGSL 500 SNMAKPRAPS 510 CRTVHNGPLG 520 NKPSNHLAGS 530 SFTLGSGEGA 540 SEVPHSRQAA 550 FSSPIETDVV 560 PDTRLLDKFS 570 QITPRLFMPL 580 DETIQNPPME 590 TLYIIDFFIA 600 LAICNTVVVS 610 APNQPRQKIR 620 HPSLGGLPIK 630 SLEEIKSLFQ 640 RWSVRRSSSP 650 SLNSGKEPSS 660 GVPNAFVSRL 670 PLFSRMKPAS 680 PVEEEVSQVC 690 ESPQCSSSSA 700 CCTETEKQHG 710 DAGLLNGKAE 720 SLPGQPLACN 730 LCYEAESPDE 740 AALVYAARAY 750 QCTLRSRTPE 760 QVMVDFAALG 770 PLTFQLLHIL 780 PFDSVRKRMS 790 VVVRHPLSNQ 800 VVVYTKGADS 810 VIMELLSVAS 820 PDGASLEKQQ 830 MIVREKTQKH 840 LDDYAKQGLR 850 TLCIAKKVMS 860 DTEYAEWLRN 870 HFLAETSIDN 880 REELLLESAM 890 RLENKLTLLG 900 ATGIEDRLQE 910 GVPESIEALH 920 KAGIKIWMLT 930 GDKQETAVNI 940 AYACKLLEPD 950 DKLFILNTQS 960 KDACGMLMST 970 ILKELQKKTQ 980 ALPEQVSLSE 990 DLLQPPVPRD 1000 SGLRAGLIIT 1010 GKTLEFALQE 1020 SLQKQFLELT 1030 SWCQAVVCCR 1040 ATPLQKSEVV 1050 KLVRSHLQVM 1060 TLAIGDGAND 1070 VSMIQVADIG 1080 IGVSGQEGMQ 1090 AVMASDFAVS 1100 QFKHLSKLLL 1110 VHGHWCYTRL 1120 SNMILYFFYK 1130 NVAYVNLLFW 1140 YQFFCGFSGT 1150 SMTDYWVLIF 1160 FNLLFTSAPP 1170 VIYGVLEKDV 1180 SAETLMQLPE 1190 LYRSGQKSEA 1200 YLPHTFWITL 1210 LDAFYQSLVC 1220 FFVPYFTYQG 1230 SDTDIFAFGN 1240 PLNTAALFIV 1250 LLHLVIESKS 1260 LTWIHLLVII 1270 GSILSYFLFA 1280 IVFGAMCVTC 1290 NPPSNPYWIM 1300 QEHMLDPVFY 1310 LVCILTTSIA 1320 LLPRFVYRVL 1330 QGSLFPSPIL 1340 RAKHFDRLTP 1350 EERTKALKKW 1360 RGAGKMNQVT 1370 SKYANQSAGK 1380 SGRRPMPGPS 1390 AVFAMKSASS 1400 CAIEQGNLSL 1410 CETALDQGYS 1420 ETKAFEMAGP SKGKES

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0016020	membrane
Cellular Component	GO:1990531	phospholipid-translocating ATPase complex
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0140326	ATPase-coupled intramembrane lipid transporter activity
Molecular Function	GO:0140351	glycosylceramide flippase activity
Molecular Function	GO:0000287	magnesium ion binding
Biological Process	GO:0006812	monoatomic cation transport
Biological Process	GO:0034220	monoatomic ion transmembrane transport
Biological Process	GO:0045332	phospholipid translocation

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.