Search Results

Overview

Uniprot ID	Q9P287
Protein Name	BRCA2 and CDKN1A-interacting protein
Gene Name	BCCIP
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
231	KTFVEAGKNNSKKKP
235	EAGKNNSKKKPSNKK

Function

During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole (PubMed:28394342). Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta (PubMed:28394342). May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ)

Protein Sequence

10 MASRSKRRAV 20 ESGVPQPPDP 30 PVQRDEEEEK 40 EVENEDEDDD 50 DSDKEKDEED 60 EVIDEEVNIE 70 FEAYSLSDND 80 YDGIKKLLQQ 90 LFLKAPVNTA 100 ELTDLLIQQN 110 HIGSVIKQTD 120 VSEDSNDDMD 130 EDEVFGFISL 140 LNLTERKGTQ 150 CVEQIQELVL 160 RFCEKNCEKS 170 MVEQLDKFLN 180 DTTKPVGLLL 190 SERFINVPPQ 200 IALPMYQQLQ 210 KELAGAHRTN 220 KPCGKCYFYL 230 LISKTFVEAG 240 KNNSKKKPSN 250 KKKAALMFAN 260 AEEEFFYEKA 270 ILKFNYSVQE 280 ESDTCLGGKW 290 SFDDVPMTPL 300 RTVMLIPGDK 310 MNEIMDKLKE YLSV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005814	centriole
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0097431	mitotic spindle pole
Cellular Component	GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0019207	kinase regulator activity
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0015631	tubulin binding
Biological Process	GO:0006281	DNA repair
Biological Process	GO:0000132	establishment of mitotic spindle orientation
Biological Process	GO:0034453	microtubule anchoring
Biological Process	GO:0000226	microtubule cytoskeleton organization
Biological Process	GO:0090307	mitotic spindle assembly
Biological Process	GO:0007052	mitotic spindle organization
Biological Process	GO:0061101	neuroendocrine cell differentiation
Biological Process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.