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Overview

Uniprot IDQ9P289
Protein NameSerine/threonine-protein kinase 26
Gene NameSTK26
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
257 FIDACLNKDPSFRPT
280 FIVKNSKKTSYLTEL

Function

Serine/threonine-protein kinase that acts as a mediator of cell growth (PubMed:11641781, PubMed:17360971). Modulates apoptosis (PubMed:11641781, PubMed:17360971). In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Phosphorylates ATG4B at 'Ser-383', thereby increasing autophagic flux (PubMed:29232556). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753)

Protein Sequence

10 MAHSPVAVQV 20 PGMQNNIADP 30 EELFTKLERI 40 GKGSFGEVFK 50 GIDNRTQQVV 60 AIKIIDLEEA 70 EDEIEDIQQE 80 ITVLSQCDSS 90 YVTKYYGSYL 100 KGSKLWIIME 110 YLGGGSALDL 120 LRAGPFDEFQ 130 IATMLKEILK 140 GLDYLHSEKK 150 IHRDIKAANV 160 LLSEQGDVKL 170 ADFGVAGQLT 180 DTQIKRNTFV 190 GTPFWMAPEV 200 IQQSAYDSKA 210 DIWSLGITAI 220 ELAKGEPPNS 230 DMHPMRVLFL 240 IPKNNPPTLV 250 GDFTKSFKEF 260 IDACLNKDPS 270 FRPTAKELLK 280 HKFIVKNSKK 290 TSYLTELIDR 300 FKRWKAEGHS 310 DDESDSEGSD 320 SESTSRENNT 330 HPEWSFTTVR 340 KKPDPKKVQN 350 GAEQDLVQTL 360 SCLSMIITPA 370 FAELKQQDEN 380 NASRNQAIEE 390 LEKSIAVAEA 400 ACPGITDKMV 410 KKLIEKFQKC SADESP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0071944 cell periphery
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0090443 FAR/SIN/STRIPAK complex
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0005798 Golgi-associated vesicle
Cellular Component GO:0016020 membrane
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0012506 vesicle membrane
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0004672 protein kinase activity
Molecular Function GO:0106310 protein serine kinase activity
Molecular Function GO:0004674 protein serine/threonine kinase activity
Biological Process GO:0006915 apoptotic process
Biological Process GO:0034599 cellular response to oxidative stress
Biological Process GO:0009267 cellular response to starvation
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0030336 negative regulation of cell migration
Biological Process GO:1903698 positive regulation of microvillus assembly
Biological Process GO:0046777 protein autophosphorylation
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0042981 regulation of apoptotic process

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.