Search Results
Overview
| Uniprot ID | Q9P2B4 |
|---|---|
| Protein Name | CTTNBP2 N-terminal-like protein |
| Gene Name | CTTNBP2NL |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 261 | NREENRTKTLKEEME |
| 271 | KEEMESLKKIVKDLE |
Function
Regulates lamellipodial actin dynamics in a CTTN-dependent manner (By similarity). Associates with core striatin-interacting phosphatase and kinase (STRIPAK) complex to form CTTNBP2NL-STRIPAK complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753)
Protein Sequence
10
MNLEKLSKPE
20
LLTLFSILEG
30
ELEARDLVIE
40
ALKAQHRDTF
50
IEERYGKYNI
60
SDPLMALQRD
70
FETLKEKNDG
80
EKQPVCTNPL
90
SILKVVMKQC
100
KNMQERMLSQ
110
LAAAESRHRK
120
VILDLEEERQ
130
RHAQDTAEGD
140
DVTYMLEKER
150
ERLTQQLEFE
160
KSQVKKFEKE
170
QKKLSSQLEE
180
ERSRHKQLSS
190
MLVLECKKAT
200
NKAAEEGQKA
210
GELSLKLEKE
220
KSRVSKLEEE
230
LAAERKRGLQ
240
TEAQVEKQLS
250
EFDIEREQLR
260
AKLNREENRT
270
KTLKEEMESL
280
KKIVKDLEAS
290
HQHSSPNEQL
300
KKPVTVSKGT
310
ATEPLMLMSV
320
FCQTESFPAE
330
RTHGSNIAKM
340
TNTGLPGPAT
350
PAYSYAKTNG
360
HCDPEIQTTR
370
ELTAGNNVEN
380
QVPPREKSVA
390
LAQEKPVENG
400
GCPVGIETPV
410
PMPSPLSSSG
420
SSLSPSSTAS
430
SSLTSSPCSS
440
PVLTKRLLGS
450
SASSPGYQSS
460
YQVGINQRFH
470
AARHKFQSQA
480
DQDQQASGLQ
490
SPPSRDLSPT
500
LIDNSAAKQL
510
ARNTVTQVLS
520
RFTSQQGPIK
530
PVSPNSSPFG
540
TDYRNLANTA
550
NPRGDTSHSP
560
TPGKVSSPLS
570
PLSPGIKSPT
580
IPRAERGNPP
590
PIPPKKPGLT
600
PSPSATTPLT
610
KTHSQAASLT
620
TAEDLASSCS
630
SNTVVANGKD
VELLLPTSS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0090443 | FAR/SIN/STRIPAK complex |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0001725 | stress fiber |
| Molecular Function | GO:0051721 | protein phosphatase 2A binding |
| Biological Process | GO:0034763 | negative regulation of transmembrane transport |
| Biological Process | GO:0032410 | negative regulation of transporter activity |
| Biological Process | GO:0006470 | protein dephosphorylation |
| Biological Process | GO:1903119 | protein localization to actin cytoskeleton |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.