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Overview

Uniprot IDQ9P2D3
Protein NameHEAT repeat-containing protein 5B
Gene NameHEATR5B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1419 ESATTMEKLAVLKAW

Function

Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025)

Protein Sequence

10 MELAHSLLLN 20 EEALAQITEA 30 KRPVFIFEWL 40 RFLDKVLVAA 50 NKTDVKEKQK 60 KLVEQLTGLI 70 SSSPGPPTRK 80 LLAKNLAALY 90 SIGDTFTVFQ 100 TLDKCNDIIR 110 NKDDTAAYLP 120 TKLAAVACVG 130 AFYEKMGRML 140 GSAFPETVNN 150 LLKSLKSAES 160 QGRSEILMSL 170 QKVLSGLGGA 180 AASSHRDIYK 190 NARSLLTDRS 200 MAVRCAVAKC 210 LLELQNEAVF 220 MWTAELENIA 230 TLCFKALENS 240 NYGVRVAVSK 250 LLGTVMATAL 260 MPKQATVMRQ 270 NVKRATFDEV 280 LELMATGFLR 290 GGSGFLKSGG 300 EMLKVGGSVN 310 REVRVGVTQA 320 YVVFVTTLGG 330 QWLERSFATF 340 LSHVLDLVSH 350 PRATQTHVEA 360 VYSRRCVSFI 370 LRATVGSLLG 380 EKAQIAAAKE 390 ICQAIGKQMK 400 AVEAVVNDTS 410 GENKSGAADI 420 AASQHVMVCA 430 LQELGSLVQS 440 LNATASPLIQ 450 EASIGLLEIV 460 TSVLLHPSMA 470 ARLAAAWCLR 480 CVAVALPFQL 490 TPFLDRCAER 500 LNNLKTSPEA 510 VSGYSFAMAA 520 LLGGVHQCPL 530 GIPHAKGKMV 540 VSIAEDLLRT 550 AAQNSRLSLQ 560 RTQAGWLLLG 570 ALMTLGPSVV 580 RYHLPKMLLL 590 WRNVFPRSLK 600 ELEAEKARGD 610 SFTWQVTLEG 620 RAGALCAMRS 630 FVAHCPELLT 640 EDVIRKLMTP 650 IECAMTMMSH 660 IPSVMKAHGA 670 HLKASAAMVR 680 LRLYDILALL 690 PPKTYEGSFN 700 ALLRELVAEF 710 TLTDNSANTT 720 TSLLRSLCHY 730 DDSVLLGSWL 740 QETDHKSIED 750 QLQPNSASGS 760 GALEHDPSSI 770 YLRIPAGEAV 780 PGPLPLGVSV 790 IDASVALFGV 800 VFPHVSYKHR 810 LQMLDHFAEC 820 VKQAKGVRQQ 830 AVQLNIFTAV 840 LSALKGLAEN 850 KSTLGPEEVR 860 KSALTLVMGP 870 LDNPNPILRC 880 AAGEALGRMA 890 QVVGEATFIA 900 RMAQYSFDKL 910 KSARDVVSRT 920 GHSLALGCLH 930 RYVGGIGSGQ 940 HLKTSVSILL 950 ALAQDGTSPE 960 VQTWSLHSLA 970 LIVDSSGPMY 980 RGYVEPTLSL 990 VLTLLLTVPP 1000 SHTEVHQCLG 1010 RCLGAIITTV 1020 GPELQGNGAT 1030 TSTIRSSCLV 1040 GCAITQDHSD 1050 SLVQAAAISC 1060 LQQLHMFAPR 1070 HVNLSSLVPS 1080 LCVHLCSSHL 1090 LLRRAAVACL 1100 RQLAQREAAE 1110 VCEYAMSLAK 1120 NTGDKESSSA 1130 NVSPFAPGVS 1140 SRTDIHCRHQ 1150 GVNITETGLE 1160 GLLFGMLDRE 1170 TDRKLCSDIH 1180 DTLGHMLSSL 1190 AVEKLSHWLM 1200 LCKDVLAASS 1210 DMSTATLLSS 1220 GKDEEAEKKD 1230 EMDDDTMFTT 1240 LGEEDKSKPF 1250 VAPRWATRVF 1260 AADCLCRIIN 1270 LCENADQAHF 1280 DLALARSAKL 1290 RNPTNDLLVL 1300 HLSDLIRMAF 1310 MAATDHSNQL 1320 RMAGLQALED 1330 IIKKFASVPE 1340 PEFPGHVILE 1350 QYQANVGAAL 1360 RPAFSQDTPS 1370 DIIAKACQVC 1380 STWIGSGVVS 1390 DLNDLRRVHN 1400 LLVSSLDKVQ 1410 AGKGSSSQLY 1420 RESATTMEKL 1430 AVLKAWAEVY 1440 VVAMNIKKEA 1450 ESKPKRAIKN 1460 TDDDDDDCGT 1470 IDELPPDSLI 1480 TLVQPELPTL 1490 SRLWLAALKD 1500 YALLTLPAEF 1510 SSQLPPDGGA 1520 FYTPETIDTA 1530 RLHYRNSWAP 1540 ILHAVALWLN 1550 STGFTCSEST 1560 EAAAISGLQK 1570 RSTSVNLNQA 1580 SGAVGSAKSL 1590 PEINKDRMHL 1600 ILGVSIQFLC 1610 SPRPEEPIEH 1620 VTACLQALHT 1630 LLDSPYARVH 1640 IAEDQLIGVE 1650 LLSVLHRLLL 1660 TWNPSSVQLL 1670 VTGVVQQIVR 1680 AAQDYLQEKR 1690 NTLNEDDMEK 1700 EACTVLGEGG 1710 DSGGLIPGKS 1720 LVFATMELLM 1730 FILVRHMPHL 1740 STKVSDSPSH 1750 IATKTRLSEE 1760 SARLVAATVT 1770 ILSDLPSLCS 1780 PAGCMTILPT 1790 ILFLIARILK 1800 DTAIKSADNQ 1810 VPPPVSAALQ 1820 GIKSIVTLSM 1830 AKTEAGVQKQ 1840 WTALIRSTLA 1850 CILEYSQPED 1860 SVPTPDEVSM 1870 LTAIALFLWS 1880 ASNEIIGVQS 1890 LQNGCMNRFK 1900 NALNSCDPWV 1910 QAKCYQLLLS 1920 VFQHSNRALS 1930 TPYIHSLAPI 1940 VVEKLKAVER 1950 NRPASNIELL 1960 AVQEGIKVLE 1970 TLVALGEEQN 1980 RVQLLALLVP 1990 TLISYLLDEN 2000 SFASASSASK 2010 DLHEFALQNL 2020 MHIGPLYPHA 2030 FKTVMGAAPE 2040 LKVRLETAVR 2050 ASQASKAKAA 2060 ARQPAPAIHS 2070 APTIKLKTSF F

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030136 clathrin-coated vesicle
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030139 endocytic vesicle
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0016020 membrane
Cellular Component GO:0048471 perinuclear region of cytoplasm
Biological Process GO:0006897 endocytosis
Biological Process GO:0008104 intracellular protein localization
Biological Process GO:0015031 protein transport
Biological Process GO:0042147 retrograde transport, endosome to Golgi

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.