Search Results

Overview

Uniprot IDQ9P2D7
Protein NameDynein axonemal heavy chain 1
Gene NameDNAH1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
604 RKLMELVKYMLQDTL

Function

Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (PubMed:24360805)

Protein Sequence

10 MEQPNSKGYS 20 LGRTPQGPEC 30 SSAPAVQVGT 40 HRGLEYNPGK 50 ILPGSDYGLG 60 NPPALDPKLP 70 HLPLPPAPPT 80 LSDLGQPRKS 90 PLTGTDKKYP 100 LMKQRGFYSD 110 ILSPGTLDQL 120 GEVCRGPRMS 130 QNLLRQADLD 140 KFTPRVGSFE 150 VPEDFQERME 160 QQCIGSTTRL 170 LAQTDFPLQA 180 YEPKMQVPFQ 190 VLPGQHPRKI 200 EIERRKQQYL 210 SLDIEQLLFS 220 QGIDSNKLMP 230 RHLDHQHPQT 240 IEQGHDPIFP 250 IYLPLKVFDN 260 EDFDCRTPRE 270 WINMGLEPGS 280 LDRKPVPGKA 290 LLPTDDFLGH 300 EDPKSQKLKY 310 KWCEVGVLDY 320 DEEKKLYLVH 330 KTDEKGLVRD 340 EMGRPILNAG 350 VTTEGRPPLQ 360 VCQYWVPRIQ 370 LLFCAEDPCM 380 FAQRVVQANA 390 LRKNTEALLL 400 YNLYVDCMPS 410 DGQHVISEQS 420 LSKIKQWALS 430 TPRMRKGPSV 440 LEHLSSLARE 450 VSLDYERSMN 460 KINFDHVVSS 470 KPETFSYVTL 480 PKKEEEQVPE 490 RGLVSVPKYH 500 FWEQKEDFTF 510 VSLLTRPEVI 520 TALSKVRAEC 530 NKVTAMSLFH 540 SSLSKYSHLE 550 EFEQIQSQTF 560 SQVQMFLKDS 570 WISSLKVAMR 580 SSLRDMSKGW 590 YNLYETNWEV 600 YLMSKLRKLM 610 ELVKYMLQDT 620 LRFLVQDSLA 630 SFSQFISDTC 640 CSVLNCTDDM 650 VWGDDLINSP 660 YRPRKNPLFI 670 MDLVLDSSGV 680 HYSTPLEQFE 690 ASLLNLFDKG 700 ILATHAVPQL 710 EKLVMEDIFI 720 SGDPLLESVG 730 LHEPLVEELR 740 ATIASAVSKA 750 MIPLQAYAKE 760 YRKYLELNNN 770 DIASFLKTYQ 780 TQGLLAQEVR 790 EVVLTHLREK 800 EILDSSLPSS 810 IIIGPFYINT 820 DNVKQSLSKK 830 RKALATSVLD 840 ILAKNLHKEV 850 DSICEEFRSI 860 SRKIYEKPNS 870 IEELAELREW 880 MKGIPERLVG 890 LEERIVKVMD 900 DYQVMDEFLY 910 NLSSDDFNDK 920 WIASNWPSKI 930 LGQIELVQQQ 940 HVEDEEKFRK 950 IQIMDQNNFQ 960 EKLEGLQLVV 970 AGFSIHVEIS 980 RAHEIANEVR 990 RVKKQLKDCQ 1000 QLAMLYNNRE 1010 RIFSLPITNY 1020 DKLSRMVKEF 1030 QPYLDLWTTA 1040 SDWLRWSESW 1050 MNDPLSAIDA 1060 EQLEKNVVEA 1070 FKTMHKCVKQ 1080 FKDMPACQEV 1090 ALDIRARIEE 1100 FKPYIPLIQG 1110 LRNPGMRIRH 1120 WETLSNQINI 1130 NVRPKANLTF 1140 ARCLEMNLQD 1150 HIESISKVAE 1160 VAGKEYAIEQ 1170 ALDKMEKEWS 1180 TILFNVLPYK 1190 ATDTYILKSP 1200 DEASQLLDDH 1210 IVMTQNMSFS 1220 PYKKPFEQRI 1230 NSWENKLKLT 1240 QEVLEEWLNC 1250 QRSWLYLEPI 1260 FSSEDINQQL 1270 PVESKRYQTM 1280 ERIWKKIMKN 1290 AYENREVINV 1300 CSDLRMLDSL 1310 RDCNKILDLV 1320 QKGLSEYLET 1330 KRSAFPRFYF 1340 LSDDELLEIL 1350 SQTKDPTAVQ 1360 PHLRKCFENI 1370 ARLLFQEDLE 1380 ITHMYSAEGE 1390 EVQLCFSIYP 1400 SSNVEDWLRE 1410 VERSMKASVH 1420 DIIEKAIRAY 1430 PTMPRTQWVL 1440 NWPGQVTIAG 1450 CQTYWTMEVA 1460 EALEAGNLRS 1470 QLFPQLCQQL 1480 SDLVALVRGK 1490 LSRMQRAVLS 1500 ALIVIEVHAK 1510 DVVSKLIQEN 1520 VVSVNDFQWI 1530 SQLRYYWTNN 1540 DLYIRAVNAE 1550 FIYGYEYLGN 1560 SGRLVITPLT 1570 DRCYLTLTGA 1580 LHLKFGGAPA 1590 GPAGTGKTET 1600 TKDLGKALAI 1610 QTVVFNCSDQ 1620 LDFMAMGKFF 1630 KGLASAGAWA 1640 CFDEFNRIDI 1650 EVLSVVAQQI 1660 TTIQKAQQQR 1670 VERFMFEGVE 1680 IPLVPSCAVF 1690 ITMNPGYAGR 1700 TELPDNLKAL 1710 FRPVAMMVPD 1720 YAMITEISLY 1730 SFGFNEASVL 1740 AKKITTTFKL 1750 SSEQLSSQDH 1760 YDFGMRAVKT 1770 VISAAGNLKR 1780 ENPSMNEELI 1790 CLRAIRDVNV 1800 PKFLQEDLKL 1810 FSGIVSDLFP 1820 TIKEEDTDYG 1830 ILDEAIREAC 1840 RNSNLKDVEG 1850 FLTKCIQLYE 1860 TTVVRHGLML 1870 VGPTGSGKST 1880 CYRVLAAAMT 1890 SLKGQPSISG 1900 GMYEAVNYYV 1910 LNPKSITMGQ 1920 LYGEFDLLTH 1930 EWTDGIFSSF 1940 IRAGAITSDT 1950 NKKWYMFDGP 1960 VDAIWIENMN 1970 TVLDDNKKLC 1980 LSSGEIIKLT 1990 EAMTMMFEVQ 2000 DLAVASPATV 2010 SRCGMVYLEP 2020 SILGLMPFIE 2030 CWLRKLPPLL 2040 KPYEEHFKAL 2050 FVSFLEESIS 2060 FVRSSVKEVI 2070 ASTNCNLTMS 2080 LLKLLDCFFK 2090 PFLPREGLKK 2100 IPSEKLSRIV 2110 ELIEPWFIFS 2120 LIWSVGATGD 2130 SSGRTSFSHW 2140 LRLKMENEQL 2150 TLLFPEEGLV 2160 FDYRLEDAGI 2170 SGTNDSEDEE 2180 EEYKQVAWVK 2190 WMDSSAPFTM 2200 VPDTNYCNII 2210 VPTMDTVQMS 2220 HLLDMLLTNK 2230 KPVLCIGPTG 2240 TGKTLTISDK 2250 LLKNLALDYI 2260 SHFLTFSART 2270 SANQTQDFID 2280 SKLDKRRKGV 2290 FGPPLGRNFI 2300 FFIDDLNMPA 2310 LETYGAQPPI 2320 ELLRQWMDHG 2330 GWYDRKIIGA 2340 FKNLVDINFV 2350 CAMGPPGGGR 2360 NTVTPRLMRH 2370 FNYLSFAEMD 2380 EVSKKRIFST 2390 ILGNWLDGLL 2400 GEKSYRERVP 2410 GAPHIAHFTE 2420 PLVEATIMVY 2430 ATITSQLLPT 2440 PAKSHYTFNL 2450 RDLSKVFQGM 2460 LMADPAKVED 2470 QVQLLRLWYH 2480 ENCRVFRDRL 2490 VNEEDRSWFD 2500 QLLKRCMEQW 2510 EVTFNKVCPF 2520 QPILYGDFMS 2530 PGSDVKSYEL 2540 ITSESKMMQV 2550 IEEYIEDYNQ 2560 INTAKLKLVL 2570 FMDAMSHICR 2580 ISRTLRQALG 2590 NALLLGVGGS 2600 GRSSLTRLAS 2610 HMAEYECFQI 2620 ELSKNYGMSE 2630 WRDDVKKVLL 2640 KAGLQNLPIT 2650 FLFSDTQIKN 2660 ESFLEDINNV 2670 LNSGDIPNLY 2680 TADEQDQIVS 2690 TMRPYIQEQG 2700 LQPTKANLMA 2710 AYTGRVRSNI 2720 HMVLCMSPIG 2730 EVFRARLRQF 2740 PSLVNCCTID 2750 WFNEWPAEAL 2760 KSVATVFLNE 2770 IPELESSQEE 2780 IQGLIQVCVY 2790 IHQSVSKKCI 2800 EYLAELTRHN 2810 YVTPKSYLEL 2820 LHIFSILIGQ 2830 KKLELKTAKN 2840 RMKSGLDKLL 2850 RTSEDVAKMQ 2860 EDLESMHPLL 2870 EEAAKDTMLT 2880 MEQIKVDTAI 2890 AEETRNSVQT 2900 EEIKANEKAK 2910 KAQAIADDAQ 2920 KDLDEALPAL 2930 DAALASLRNL 2940 NKNDVTEVRA 2950 MQRPPPGVKL 2960 VIEAVCIMKG 2970 IKPKKVPGEK 2980 PGTKVDDYWE 2990 PGKGLLQDPG 3000 HFLESLFKFD 3010 KDNIGDVVIK 3020 AIQPYIDNEE 3030 FQPATIAKVS 3040 KACTSICQWV 3050 RAMHKYHFVA 3060 KAVEPKRQAL 3070 LEAQDDLGVT 3080 QRILDEAKQR 3090 LREVEDGIAT 3100 MQAKYRECIT 3110 KKEELELKCE 3120 QCEQRLGRAG 3130 KLINGLSDEK 3140 VRWQETVENL 3150 QYMLNNISGD 3160 VLVAAGFVAY 3170 LGPFTGQYRT 3180 VLYDSWVKQL 3190 RSHNVPHTSE 3200 PTLIGTLGNP 3210 VKIRSWQIAG 3220 LPNDTLSVEN 3230 GVINQFSQRW 3240 THFIDPQSQA 3250 NKWIKNMEKD 3260 NGLDVFKLSD 3270 RDFLRSMENA 3280 IRFGKPCLLE 3290 NVGEELDPAL 3300 EPVLLKQTYK 3310 QQGNTVLKLG 3320 DTVIPYHEDF 3330 RMYITTKLPN 3340 PHYTPEISTK 3350 LTLINFTLSP 3360 SGLEDQLLGQ 3370 VVAEERPDLE 3380 EAKNQLIISN 3390 AKMRQELKDI 3400 EDQILYRLSS 3410 SEGNPVDDME 3420 LIKVLEASKM 3430 KAAEIQAKVR 3440 IAEQTEKDID 3450 LTRMEYIPVA 3460 IRTQILFFCV 3470 SDLANVDPMY 3480 QYSLEWFLNI 3490 FLSGIANSER 3500 ADNLKKRISN 3510 INRYLTYSLY 3520 SNVCRSLFEK 3530 HKLMFAFLLC 3540 VRIMMNEGKI 3550 NQSEWRYLLS 3560 GGSISIMTEN 3570 PAPDWLSDRA 3580 WRDILALSNL 3590 PTFSSFSSDF 3600 VKHLSEFRVI 3610 FDSLEPHREP 3620 LPGIWDQYLD 3630 QFQKLLVLRC 3640 LRGDKVTNAM 3650 QDFVATNLEP 3660 RFIEPQTANL 3670 SVVFKDSNST 3680 TPLIFVLSPG 3690 TDPAADLYKF 3700 AEEMKFSKKL 3710 SAISLGQGQG 3720 PRAEAMMRSS 3730 IERGKWVFFQ 3740 NCHLAPSWMP 3750 ALERLIEHIN 3760 PDKVHRDFRL 3770 WLTSLPSNKF 3780 PVSILQNGSK 3790 MTIEPPRGVR 3800 ANLLKSYSSL 3810 GEDFLNSCHK 3820 VMEFKSLLLS 3830 LCLFHGNALE 3840 RRKFGPLGFN 3850 IPYEFTDGDL 3860 RICISQLKMF 3870 LDEYDDIPYK 3880 VLKYTAGEIN 3890 YGGRVTDDWD 3900 RRCIMNILED 3910 FYNPDVLSPE 3920 HSYSASGIYH 3930 QIPPTYDLHG 3940 YLSYIKSLPL 3950 NDMPEIFGLH 3960 DNANITFAQN 3970 ETFALLGTII 3980 QLQPKSSSAG 3990 SQGREEIVED 4000 VTQNILLKVP 4010 EPINLQWVMA 4020 KYPVLYEESM 4030 NTVLVQEVIR 4040 YNRLLQVITQ 4050 TLQDLLKALK 4060 GLVVMSSQLE 4070 LMAASLYNNT 4080 VPELWSAKAY 4090 PSLKPLSSWV 4100 MDLLQRLDFL 4110 QAWIQDGIPA 4120 VFWISGFFFP 4130 QAFLTGTLQN 4140 FARKFVISID 4150 TISFDFKVMF 4160 EAPSELTQRP 4170 QVGCYIHGLF 4180 LEGARWDPEA 4190 FQLAESQPKE 4200 LYTEMAVIWL 4210 LPTPNRKAQD 4220 QDFYLCPIYK 4230 TLTRAGTLST 4240 TGHSTNYVIA 4250 VEIPTHQPQR 4260 HWIKRGVALI CALDY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005858 axonemal dynein complex
Cellular Component GO:0005930 axoneme
Cellular Component GO:0030286 dynein complex
Cellular Component GO:0036156 inner dynein arm
Cellular Component GO:0005874 microtubule
Cellular Component GO:0036126 sperm flagellum
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0045505 dynein intermediate chain binding
Molecular Function GO:0051959 dynein light intermediate chain binding
Molecular Function GO:0003777 microtubule motor activity
Molecular Function GO:0008569 minus-end-directed microtubule motor activity
Biological Process GO:0060285 cilium-dependent cell motility
Biological Process GO:0030317 flagellated sperm motility
Biological Process GO:0036159 inner dynein arm assembly
Biological Process GO:0007288 sperm axoneme assembly

Reference

[1] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.