Search Results

Overview

Uniprot IDQ9P2D8
Protein NameProtein unc-79 homolog
Gene NameUNC79
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1303 ESDISSAKAFNTVKR

Function

Auxilary subunit of the NALCN channelosome complex, which regulates the resting membrane potential by depolarizing sodium leak currents (PubMed:32494638, PubMed:35387979, PubMed:34929720). The NALCN channelosome complex is a voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability (PubMed:35387979, PubMed:34929720). The NALCN channelosome is constitutively active and conducts monovalent cations but is blocked by physiological concentrations of extracellular divalent cations (PubMed:32494638). Activated by neuropeptides substance P, neurotensin, and extracellular Ca(2+) that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current (By similarity)

Protein Sequence

10 MSTKAEQFAS 20 KIRYLQEYHN 30 RVLHNIYPVP 40 SGTDIANTLK 50 YFSQTLLSIL 60 SRTGKKENQD 70 ASNLTVPMTM 80 CLFPVPFPLT 90 PSLRPQVSSI 100 NPTVTRSLLY 110 SVLRDAPSER 120 GPQSRDAQLS 130 DYPSLDYQGL 140 YVTLVTLLDL 150 VPLLQHGQHD 160 LGQSIFYTTT 170 CLLPFLNDDI 180 LSTLPYTMIS 190 TLATFPPFLH 200 KDIIEYLSTS 210 FLPMAILGSS 220 RREGVPAHVN 230 LSASSMLMIA 240 MQYTSNPVYH 250 CQLLECLMKY 260 KQEVWKDLLY 270 VIAYGPSQVK 280 PPAVQMLFHY 290 WPNLKPPGAI 300 SEYRGLQYTA 310 WNPIHCQHIE 320 CHNAINKPAV 330 KMCIDPSLSV 340 ALGDKPPPLY 350 LCEECSERIA 360 GDHSEWLIDV 370 LLPQAEISAI 380 CQKKNCSSHV 390 RRAVVTCFSA 400 GCCGRHGNRP 410 VRYCKRCHSN 420 HHSNEVGAAA 430 ETHLYQTSPP 440 PINTRECGAE 450 ELVCAVEAVI 460 SLLKEAEFHA 470 EQREHELNRR 480 RQLGLSSSHH 490 SLDNADFDNK 500 DDDKHDQRLL 510 SQFGIWFLVS 520 LCTPSENTPT 530 ESLARLVAMV 540 FQWFHSTAYM 550 MDDEVGSLVE 560 KLKPQFVTKW 570 LKTVCDVRFD 580 VMVMCLLPKP 590 MEFARVGGYW 600 DKSCSTVTQL 610 KEGLNRILCL 620 IPYNVINQSV 630 WECIMPEWLE 640 AIRTEVPDNQ 650 LKEFREVLSK 660 MFDIELCPLP 670 FSMEEMFGFI 680 SCRFTGYPSS 690 VQEQALLWLH 700 VLSELDIMVP 710 LQLLISMFSD 720 GVNSVKELAN 730 QRKSRVSELA 740 GNLASRRVSV 750 ASDPGRRVQH 760 NMLSPFHSPF 770 QSPFRSPLRS 780 PFRSPFKNFG 790 HPGGRTIDFD 800 CEDDEMNLNC 810 FILMFDLLLK 820 QMELQDDGIT 830 MGLEHSLSKD 840 IISIINNVFQ 850 APWGGSHTCQ 860 KDEKAIECNL 870 CQSSILCYQL 880 ACELLERLAP 890 KEESRLVEPT 900 DSLEDSLLSS 910 RPEFIIGPEG 920 EEEENPASKH 930 GENPGNCTEP 940 VEHAAVKNDT 950 ERKFCYQQLP 960 VTLRLIYTIF 970 QEMAKFEEPD 980 ILFNMLNCLK 990 ILCLHGECLY 1000 IARKDHPQFL 1010 AYIQDHMLIA 1020 SLWRVVKSEF 1030 SQLSSLAVPL 1040 LLHALSLPHG 1050 ADIFWTIING 1060 NFNSKDWKMR 1070 FEAVEKVAVI 1080 CRFLDIHSVT 1090 KNHLLKYSLA 1100 HAFCCFLTAV 1110 EDVNPAVATR 1120 AGLLLDTIKR 1130 PALQGLCLCL 1140 DFQFDTVVKD 1150 RPTILSKLLL 1160 LHFLKQDIPA 1170 LSWEFFVNRF 1180 ETLSLEAQLH 1190 LDCNKEFPFP 1200 TTITAVRTNV 1210 ANLSDAALWK 1220 IKRARFARNR 1230 QKSVRSLRDS 1240 VKGPVESKRA 1250 LSLPETLTSK 1260 IRQQSPENDN 1270 TIKDLLPEDA 1280 GIDHQTVHQL 1290 ITVLMKFMAK 1300 DESSAESDIS 1310 SAKAFNTVKR 1320 HLYVLLGYDQ 1330 QEGCFMIAPQ 1340 KMRLSTCFNA 1350 FIAGIAQVMD 1360 YNINLGKHLL 1370 PLVVQVLKYC 1380 SCPQLRHYFQ 1390 QPPRCSLWSL 1400 KPHIRQMWLK 1410 ALLVILYKYP 1420 YRDCDISKIL 1430 LHLIHITVNT 1440 LNAQYHSCKP 1450 HATAGPLYSD 1460 NSNISRYSEK 1470 EKGEIELAEY 1480 RETGALQDSL 1490 LHCVREESIP 1500 KKKLRSFKQK 1510 SLDIGNADSL 1520 LFTLDEHRRK 1530 SCIDRCDIEK 1540 PPTQAAYIAQ 1550 RPNDPGRSRQ 1560 NSATRPDNSE 1570 IPENPAMEGF 1580 PDARRPVIPE 1590 VRLNCMETFE 1600 VKVDSPVKPA 1610 PKEDLDLIDL 1620 SSDSTSGPEK 1630 HSILSTSDSD 1640 SLVFEPLPPL 1650 RIVESDEEEE 1660 TMNQGDDGPS 1670 GKNAASSPSV 1680 PSHPSVLSLS 1690 TAPLVQVSVE 1700 DCSKDFSSKD 1710 SGNNQSAGNT 1720 DSALITLEDP 1730 MDAEGSSKPE 1740 ELPEFSCGSP 1750 LTLKQKRDLL 1760 QKSFALPEMS 1770 LDDHPDPGTE 1780 GEKPGELMPS 1790 SGAKTVLLKV 1800 PEDAENPTES 1810 EKPDTSAESD 1820 TEQNPERKVE 1830 EDGAEESEFK 1840 IQIVPRQRKQ 1850 RKIAVSAIQR 1860 EYLDISFNIL 1870 DKLGEQKDPD 1880 PSTKGLSTLE 1890 MPRESSSAPT 1900 LDAGVPETSS 1910 HSSISTQYRQ 1920 MKRGSLGVLT 1930 MSQLMKRQLE 1940 HQSSAPHNIS 1950 NWDTEQIQPG 1960 KRQCNVPTCL 1970 NPDLEGQPLR 1980 MRGATKSSLL 1990 SAPSIVSMFV 2000 PAPEEFTDEQ 2010 PTVMTDKCHD 2020 CGAILEEYDE 2030 ETLGLAIVVL 2040 STFIHLSPDL 2050 AAPLLLDIMQ 2060 SVGRLASSTT 2070 FSNQAESMMV 2080 PGNAAGVAKQ 2090 FLRCIFHQLA 2100 PNGIFPQLFQ 2110 STIKDGTFLR 2120 TLASSLMDFN 2130 ELSSIAALSQ 2140 LLEGLNNKKN 2150 LPAGGAMIRC 2160 LENIATFMEA 2170 LPMDSPSSLW 2180 TTISNQFQTF 2190 FAKLPCVLPL 2200 KCSLDSSLRI 2210 MICLLKIPST 2220 NATRSLLEPF 2230 SKLLSFVIQN 2240 AVFTLAYLVE 2250 LCGLCYRAFT 2260 KERDKFYLSR 2270 SVVLELLQAL 2280 KLKSPLPDTN 2290 LLLLVQFICA 2300 DAGTKLAEST 2310 ILSKQMIASV 2320 PGCGTAAMEC 2330 VRQYINEVLD 2340 FMADMHTLTK 2350 LKSHMKTCSQ 2360 PLHEDTFGGH 2370 LKVGLAQIAA 2380 MDISRGNHRD 2390 NKAVIRYLPW 2400 LYHPPSAMQQ 2410 GPKEFIECVS 2420 HIRLLSWLLL 2430 GSLTHNAVCP 2440 NASSPCLPIP 2450 LDAGSHVADH 2460 LIVILIGFPE 2470 QSKTSVLHMC 2480 SLFHAFIFAQ 2490 LWTVYCEQSA 2500 VATNLQNQNE 2510 FSFTAILTAL 2520 EFWSRVTPSI 2530 LQLMAHNKVM 2540 VEMVCLHVIS 2550 LMEALQECNS 2560 TIFVKLIPMW 2570 LPMIQSNIKH 2580 LSAGLQLRLQ 2590 AIQNHVNHHS 2600 LRTLPGSGQS 2610 SAGLAALRKW 2620 LQCTQFKMAQ 2630 VEIQSSEAAS QFYPL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005886 plasma membrane
Biological Process GO:0098908 regulation of neuronal action potential
Biological Process GO:0035725 sodium ion transmembrane transport

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.