Search Results

Overview

Uniprot IDQ9P2E9
Protein NameRibosome-binding protein 1
Gene NameRRBP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1014 REAVEQQKVKNNDLR
1026 DLREKNWKAMEALAT
1039 ATAEQACKEKLLSLT
1098 EKGPTLLKHPPAPAE
1159 EEQVWRAKVGAAEEE
1169 AAEEELQKSRVTVKH
1175 QKSRVTVKHLEEIVE
1185 EEIVEKLKGELESSD
1221 AECQNYAKEVAGLRQ
1241 QSQLDAAKSEAQKQS
1246 AAKSEAQKQSDELAL
1310 DEQTQRQKLTAEFEE
1358 ERLEKEKKLTSDLGR
200 ATGTTQGKKAEGTQN
211 GTQNQSKKAEGAPNQ
221 GAPNQGRKAEGTPNQ
230 EGTPNQGKKTEGTPN
240 EGTPNQGKKAEGTPN
261 GTPNQGKKAEGAQNQ
270 EGAQNQGKKVDTTPN
281 TTPNQGKKVEGAPTQ
291 GAPTQGRKAEGAQNQ
310 EGAQNQGKKAEGAQN
330 EGAQNQGKKAEGAQN
501 GAQNQGKKAEGAQNQ
511 GAQNQGQKGEGAQNQ
521 GAQNQGKKTEGAQGK
538 ERSPNQGKKGEGAPI
548 EGAPIQGKKADSVAN
559 SVANQGTKVEGITNQ
568 EGITNQGKKAEGSPS
569 GITNQGKKAEGSPSE
589 GSPNQGKKADAAANQ
599 AAANQGKKTESASVQ
620 AQSPEAPKQEAPAKK
634 KKSGSKKKGEPGPPD
677 LIEILSEKAGIIQDT
691 TWHKATQKGDPVAIL
699 GDPVAILKRQLEEKE
707 RQLEEKEKLLATEQE
720 QEDAAVAKSKLRELN
722 DAAVAKSKLRELNKE
728 SKLRELNKEMAAEKA
736 EMAAEKAKAAAGEAK
771 ASYREHVKEVQQLQG
779 EVQQLQGKIRTLQEQ
819 ATSQVESKQNAELAK
841 VSKELVEKSEAVRQD
858 QRKALEAKAAAFEKQ
864 AKAAAFEKQVLQLQA
882 ESEEALQKRLDEVSR
932 SEAEVRSKCEELSGL
990 DQQQTRLKELESQVS

Function

Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane

Protein Sequence

10 MDIYDTQTLG 20 VVVFGGFMVV 30 SAIGIFLVST 40 FSMKETSYEE 50 ALANQRKEMA 60 KTHHQKVEKK 70 KKEKTVEKKG 80 KTKKKEEKPN 90 GKIPDHDPAP 100 NVTVLLREPV 110 RAPAVAVAPT 120 PVQPPIIVAP 130 VATVPAMPQE 140 KLASSPKDKK 150 KKEKKVAKVE 160 PAVSSVVNSI 170 QVLTSKAAIL 180 ETAPKEVPMV 190 VVPPVGAKGN 200 TPATGTTQGK 210 KAEGTQNQSK 220 KAEGAPNQGR 230 KAEGTPNQGK 240 KTEGTPNQGK 250 KAEGTPNQGK 260 KAEGTPNQGK 270 KAEGAQNQGK 280 KVDTTPNQGK 290 KVEGAPTQGR 300 KAEGAQNQAK 310 KVEGAQNQGK 320 KAEGAQNQGK 330 KGEGAQNQGK 340 KAEGAQNQGK 350 KAEGAQNQGK 360 KAEGAQNQGK 370 KAEGAQNQGK 380 KAEGAQNQGK 390 KAEGAQNQGK 400 KVEGAQNQGK 410 KAEGAQNQGK 420 KAEGAQNQGK 430 KAEGAQNQGK 440 KAEGAQNQGK 450 KAEGAQNQGK 460 KAEGAQNQGK 470 KAEGAQNQGK 480 KVEGAQNQGK 490 KAEGAQNQGK 500 KAEGAQNQGK 510 KAEGAQNQGQ 520 KGEGAQNQGK 530 KTEGAQGKKA 540 ERSPNQGKKG 550 EGAPIQGKKA 560 DSVANQGTKV 570 EGITNQGKKA 580 EGSPSEGKKA 590 EGSPNQGKKA 600 DAAANQGKKT 610 ESASVQGRNT 620 DVAQSPEAPK 630 QEAPAKKKSG 640 SKKKGEPGPP 650 DADGPLYLPY 660 KTLVSTVGSM 670 VFNEGEAQRL 680 IEILSEKAGI 690 IQDTWHKATQ 700 KGDPVAILKR 710 QLEEKEKLLA 720 TEQEDAAVAK 730 SKLRELNKEM 740 AAEKAKAAAG 750 EAKVKKQLVA 760 REQEITAVQA 770 RMQASYREHV 780 KEVQQLQGKI 790 RTLQEQLENG 800 PNTQLARLQQ 810 ENSILRDALN 820 QATSQVESKQ 830 NAELAKLRQE 840 LSKVSKELVE 850 KSEAVRQDEQ 860 QRKALEAKAA 870 AFEKQVLQLQ 880 ASHRESEEAL 890 QKRLDEVSRE 900 LCHTQSSHAS 910 LRADAEKAQE 920 QQQQMAELHS 930 KLQSSEAEVR 940 SKCEELSGLH 950 GQLQEARAEN 960 SQLTERIRSI 970 EALLEAGQAR 980 DAQDVQASQA 990 EADQQQTRLK 1000 ELESQVSGLE 1010 KEAIELREAV 1020 EQQKVKNNDL 1030 REKNWKAMEA 1040 LATAEQACKE 1050 KLLSLTQAKE 1060 ESEKQLCLIE 1070 AQTMEALLAL 1080 LPELSVLAQQ 1090 NYTEWLQDLK 1100 EKGPTLLKHP 1110 PAPAEPSSDL 1120 ASKLREAEET 1130 QSTLQAECDQ 1140 YRSILAETEG 1150 MLRDLQKSVE 1160 EEEQVWRAKV 1170 GAAEEELQKS 1180 RVTVKHLEEI 1190 VEKLKGELES 1200 SDQVREHTSH 1210 LEAELEKHMA 1220 AASAECQNYA 1230 KEVAGLRQLL 1240 LESQSQLDAA 1250 KSEAQKQSDE 1260 LALVRQQLSE 1270 MKSHVEDGDI 1280 AGAPASSPEA 1290 PPAEQDPVQL 1300 KTQLEWTEAI 1310 LEDEQTQRQK 1320 LTAEFEEAQT 1330 SACRLQEELE 1340 KLRTAGPLES 1350 SETEEASQLK 1360 ERLEKEKKLT 1370 SDLGRAATRL 1380 QELLKTTQEQ 1390 LAREKDTVKK 1400 LQEQLEKAED 1410 GSSSKEGTSV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0005840 ribosome
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0038023 signaling receptor activity
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:0015031 protein transport
Biological Process GO:0006412 translation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.