Search Results
Overview
| Uniprot ID | Q9P2I0 |
|---|---|
| Protein Name | Cleavage and polyadenylation specificity factor subunit 2 |
| Gene Name | CPSF2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 444 | TKHDLMMKGEGSRKG |
| 459 | SFFKQAKKSYPMFPA |
| 584 | CCRAFGGKDIKVYMP |
Function
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing
Protein Sequence
10
MTSIIKLTTL
20
SGVQEESALC
30
YLLQVDEFRF
40
LLDCGWDEHF
50
SMDIIDSLRK
60
HVHQIDAVLL
70
SHPDPLHLGA
80
LPYAVGKLGL
90
NCAIYATIPV
100
YKMGQMFMYD
110
LYQSRHNTED
120
FTLFTLDDVD
130
AAFDKIQQLK
140
FSQIVNLKGK
150
GHGLSITPLP
160
AGHMIGGTIW
170
KIVKDGEEEI
180
VYAVDFNHKR
190
EIHLNGCSLE
200
MLSRPSLLIT
210
DSFNATYVQP
220
RRKQRDEQLL
230
TNVLETLRGD
240
GNVLIAVDTA
250
GRVLELAQLL
260
DQIWRTKDAG
270
LGVYSLALLN
280
NVSYNVVEFS
290
KSQVEWMSDK
300
LMRCFEDKRN
310
NPFQFRHLSL
320
CHGLSDLARV
330
PSPKVVLASQ
340
PDLECGFSRD
350
LFIQWCQDPK
360
NSIILTYRTT
370
PGTLARFLID
380
NPSEKITEIE
390
LRKRVKLEGK
400
ELEEYLEKEK
410
LKKEAAKKLE
420
QSKEADIDSS
430
DESDIEEDID
440
QPSAHKTKHD
450
LMMKGEGSRK
460
GSFFKQAKKS
470
YPMFPAPEER
480
IKWDEYGEII
490
KPEDFLVPEL
500
QATEEEKSKL
510
ESGLTNGDEP
520
MDQDLSDVPT
530
KCISTTESIE
540
IKARVTYIDY
550
EGRSDGDSIK
560
KIINQMKPRQ
570
LIIVHGPPEA
580
SQDLAECCRA
590
FGGKDIKVYM
600
PKLHETVDAT
610
SETHIYQVRL
620
KDSLVSSLQF
630
CKAKDAELAW
640
IDGVLDMRVS
650
KVDTGVILEE
660
GELKDDGEDS
670
EMQVEAPSDS
680
SVIAQQKAMK
690
SLFGDDEKET
700
GEESEIIPTL
710
EPLPPHEVPG
720
HQSVFMNEPR
730
LSDFKQVLLR
740
EGIQAEFVGG
750
VLVCNNQVAV
760
RRTETGRIGL
770
EGCLCQDFYR
780
IRDLLYEQYA
IV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0098794 | postsynapse |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0031124 | mRNA 3'-end processing |
| Biological Process | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage |
| Biological Process | GO:0071045 | nuclear histone mRNA catabolic process |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.