Search Results

Overview

Uniprot IDQ9P2K3
Protein NameREST corepressor 3
Gene NameRCOR3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
181 DPKKEAKKEGNTEQP
193 EQPVQTSKIGLGRRE
253 DMELISLKRQVQNAK
260 KRQVQNAKQVNSALK

Function

May act as a component of a corepressor complex that represses transcription

Protein Sequence

10 MRVGAEYQAR 20 IPEFDPGATK 30 YTDKDNGGML 40 VWSPYHSIPD 50 AKLDEYIAIA 60 KEKHGYNVEQ 70 ALGMLFWHKH 80 NIEKSLADLP 90 NFTPFPDEWT 100 VEDKVLFEQA 110 FSFHGKSFHR 120 IQQMLPDKTI 130 ASLVKYYYSW 140 KKTRSRTSLM 150 DRQARKLANR 160 HNQGDSDDDV 170 EETHPMDGND 180 SDYDPKKEAK 190 KEGNTEQPVQ 200 TSKIGLGRRE 210 YQSLQHRHHS 220 QRSKCRPPKG 230 MYLTQEDVVA 240 VSCSPNAANT 250 ILRQLDMELI 260 SLKRQVQNAK 270 QVNSALKQKM 280 EGGIEEFKPP 290 ESNQKINARW 300 TTEEQLLAVQ 310 GVRKYGKDFQ 320 AIADVIGNKT 330 VGQVKNFFVN 340 YRRRFNLEEV 350 LQEWEAEQGT 360 QASNGDASTL 370 GEETKSASNV 380 PSGKSTDEEE 390 EAQTPQAPRT 400 LGPSPPAPSS 410 TPTPTAPIAT 420 LNQPPPLLRP 430 TLPAAPALHR 440 QPPPLQQQAR 450 FIQPRPTLNQ 460 PPPPLIRPAN 470 SMPPRLNPRP 480 VLSTVGGQQP 490 PSLIGIQTDS QSSLH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0000118 histone deacetylase complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005667 transcription regulator complex
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[5] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.