Search Results

Overview

Uniprot IDQ9P2N5
Protein NameRNA-binding protein 27
Gene NameRBM27
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
574 GLEGPLTKKPWLGKQ
580 TKKPWLGKQGNNNQN
745 SGAYVLNKVPVKHRL
799 SNLKTPSKLCSGSKS
805 SKLCSGSKSHDVQEV
815 DVQEVLKKKQEAMKL
852 ISKLEKNKNMKPEER
891 SAVSTPSKVKTKTEA
893 VSTPSKVKTKTEAQK
925 DTTELRKKLSQLQVE

Function

May be involved in the turnover of nuclear polyadenylated (pA+) RNA

Protein Sequence

10 MLIEDVDALK 20 SWLAKLLEPI 30 CDADPSALAN 40 YVVALVKKDK 50 PEKELKAFCA 60 DQLDVFLQKE 70 TSGFVDKLFE 80 SLYTKNYLPL 90 LEPVKPEPKP 100 LVQEKEEIKE 110 EVFQEPAEEE 120 RDGRKKKYPS 130 PQKTRSESSE 140 RRTREKKRED 150 GKWRDYDRYY 160 ERNELYREKY 170 DWRRGRSKSR 180 SKSRGLSRSR 190 SRSRGRSKDR 200 DPNRNVEHRE 210 RSKFKSERND 220 LESSYVPVSA 230 PPPNSSEQYS 240 SGAQSIPSTV 250 TVIAPAHHSE 260 NTTESWSNYY 270 NNHSSSNSFG 280 RNLPPKRRCR 290 DYDERGFCVL 300 GDLCQFDHGN 310 DPLVVDEVAL 320 PSMIPFPPPP 330 PGLPPPPPPG 340 MLMPPMPGPG 350 PGPGPGPGPG 360 PGPGPGPGHS 370 MRLPVPQGHG 380 QPPPSVVLPI 390 PRPPITQSSL 400 INSRDQPGTS 410 AVPNLASVGT 420 RLPPPLPQNL 430 LYTVSERQPM 440 YSREHGAAAS 450 ERLQLGTPPP 460 LLAARLVPPR 470 NLMGSSIGYH 480 TSVSSPTPLV 490 PDTYEPDGYN 500 PEAPSITSSG 510 RSQYRQFFSR 520 TQTQRPNLIG 530 LTSGDMDVNP 540 RAANIVIQTE 550 PPVPVSINSN 560 ITRVVLEPDS 570 RKRAMSGLEG 580 PLTKKPWLGK 590 QGNNNQNKPG 600 FLRKNQYTNT 610 KLEVKKIPQE 620 LNNITKLNEH 630 FSKFGTIVNI 640 QVAFKGDPEA 650 ALIQYLTNEE 660 ARKAISSTEA 670 VLNNRFIRVL 680 WHRENNEQPT 690 LQSSAQLLLQ 700 QQQTLSHLSQ 710 QHHHLPQHLH 720 QQQVLVAQSA 730 PSTVHGGIQK 740 MMSKPQTSGA 750 YVLNKVPVKH 760 RLGHAGGNQS 770 DASHLLNQSG 780 GAGEDCQIFS 790 TPGHPKMIYS 800 SSNLKTPSKL 810 CSGSKSHDVQ 820 EVLKKKQEAM 830 KLQQDMRKKR 840 QEVLEKQIEC 850 QKMLISKLEK 860 NKNMKPEERA 870 NIMKTLKELG 880 EKISQLKDEL 890 KTSSAVSTPS 900 KVKTKTEAQK 910 ELLDTELDLH 920 KRLSSGEDTT 930 ELRKKLSQLQ 940 VEAARLGILP 950 VGRGKTMSSQ 960 GRGRGRGRGG 970 RGRGSLNHMV 980 VDHRPKALTV 990 GGFIEEEKED 1000 LLQHFSTANQ 1010 GPKFKDRRLQ 1020 ISWHKPKVPS 1030 ISTETEEEEV 1040 KEEETETSDL 1050 FLPDDDDEDE 1060 DEYESRSWRR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006401 RNA catabolic process

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.