Search Results

Overview

Uniprot IDQ9P2T1
Protein NameGMP reductase 2
Gene NameGMPR2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
277 SSEMAMKKYAGGVAE
291 EYRASEGKTVEVPFK
323 CTYVGAAKLKELSRR
325 YVGAAKLKELSRRTT

Function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231)

Protein Sequence

10 MPHIDNDVKL 20 DFKDVLLRPK 30 RSTLKSRSEV 40 DLTRSFSFRN 50 SKQTYSGVPI 60 IAANMDTVGT 70 FEMAKVLCKF 80 SLFTAVHKHY 90 SLVQWQEFAG 100 QNPDCLEHLA 110 ASSGTGSSDF 120 EQLEQILEAI 130 PQVKYICLDV 140 ANGYSEHFVE 150 FVKDVRKRFP 160 QHTIMAGNVV 170 TGEMVEELIL 180 SGADIIKVGI 190 GPGSVCTTRK 200 KTGVGYPQLS 210 AVMECADAAH 220 GLKGHIISDG 230 GCSCPGDVAK 240 AFGAGADFVM 250 LGGMLAGHSE 260 SGGELIERDG 270 KKYKLFYGMS 280 SEMAMKKYAG 290 GVAEYRASEG 300 KTVEVPFKGD 310 VEHTIRDILG 320 GIRSTCTYVG 330 AAKLKELSRR 340 TTFIRVTQQV NPIFSEAC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:1902560 GMP reductase complex
Molecular Function GO:0003920 GMP reductase activity
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0046037 GMP metabolic process
Biological Process GO:0006144 purine nucleobase metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.