Overview
| Uniprot ID | Q9P2X3 |
|---|
| Protein Name | Protein IMPACT |
|---|
| Gene Name | IMPACT |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 303 |
NSPEESSKALGKNKK |
Function
Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth
Protein Sequence
10
MAEGDAGSDQ
20
RQNEEIEAMA
30
AIYGEEWCVI
40
DDCAKIFCIR
50
ISDDIDDPKW
60
TLCLQVMLPN
70
EYPGTAPPIY
80
QLNAPWLKGQ
90
ERADLSNSLE
100
EIYIQNIGES
110
ILYLWVEKIR
120
DVLIQKSQMT
130
EPGPDVKKKT
140
EEEDVECEDD
150
LILACQPESS
160
LKALDFDISE
170
TRTEVEVEEL
180
PPIDHGIPIT
190
DRRSTFQAHL
200
APVVCPKQVK
210
MVLSKLYENK
220
KIASATHNIY
230
AYRIYCEDKQ
240
TFLQDCEDDG
250
ETAAGGRLLH
260
LMEILNVKNV
270
MVVVSRWYGG
280
ILLGPDRFKH
290
INNCARNILV
300
EKNYTNSPEE
310
SSKALGKNKK
320
VRKDKKRNEH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Molecular Function |
GO:0003779 |
actin binding |
| Molecular Function |
GO:0140311 |
protein sequestering activity |
| Molecular Function |
GO:0043022 |
ribosome binding |
| Biological Process |
GO:0034198 |
cellular response to amino acid starvation |
| Biological Process |
GO:0140469 |
GCN2-mediated signaling |
| Biological Process |
GO:0035556 |
intracellular signal transduction |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:1990138 |
neuron projection extension |
| Biological Process |
GO:0045666 |
positive regulation of neuron differentiation |
| Biological Process |
GO:1990611 |
regulation of cytoplasmic translational initiation in response to stress |
| Biological Process |
GO:0006446 |
regulation of translational initiation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.