Search Results
Overview
| Uniprot ID | Q9P2Y4 |
|---|---|
| Protein Name | Zinc finger protein 219 |
| Gene Name | ZNF219 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 327 | HMKVHASKLGPLRAP |
Function
Transcriptional regulator (PubMed:14621294, PubMed:19549071). Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3' (PubMed:14621294). Binds to the HMGN1 promoter and may repress HMGN1 expression (PubMed:14621294). Regulates SNCA expression in primary cortical neurons (PubMed:19549071). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity)
Protein Sequence
10
MEGSRPRAPS
20
GHLAPSPPAF
30
DGELDLQRYS
40
NGPAVSAGSL
50
GMGAVSWSES
60
RAGERRFPCP
70
VCGKRFRFNS
80
ILALHLRAHP
90
GAQAFQCPHC
100
GHRAAQRALL
110
RSHLRTHQPE
120
RPRSPAARLL
130
LELEERALLR
140
EARLGRARSS
150
GGMQATPATE
160
GLARPQAPSS
170
SAFRCPYCKG
180
KFRTSAERER
190
HLHILHRPWK
200
CGLCSFGSSQ
210
EEELLHHSLT
220
AHGAPERPLA
230
ATSAAPPPQP
240
QPQPPPQPEP
250
RSVPQPEPEP
260
EPEREATPTP
270
APAAPEEPPA
280
PPEFRCQVCG
290
QSFTQSWFLK
300
GHMRKHKASF
310
DHACPVCGRC
320
FKEPWFLKNH
330
MKVHASKLGP
340
LRAPGPASGP
350
ARAPQPPDLG
360
LLAYEPLGPA
370
LLLAPAPTPA
380
ERREPPSLLG
390
YLSLRAGEGR
400
PNGEGAEPGP
410
GRSFGGFRPL
420
SSALPARARR
430
HRAEEPEEEE
440
EVVEAEEETW
450
ARGRSLGSLA
460
SLHPRPGEGP
470
GHSASAAGAQ
480
ARSTATQEEN
490
GLLVGGTRPE
500
GGRGATGKDC
510
PFCGKSFRSA
520
HHLKVHLRVH
530
TGERPYKCPH
540
CDYAGTQSGS
550
LKYHLQRHHR
560
EQRSGAGPGP
570
PPEPPPPSQR
580
GSAPQSGAKP
590
SPQPATWVEG
600
ASSPRPPSSG
610
AGPGSRRKPA
620
SPGRTLRNGR
630
GGEAEPLDLS
640
LRAGPGGEAG
650
PGGALHRCLF
660
CPFATGAPEL
670
MALHLQVHHS
680
RRARGRRPPQ
690
ADASPPYARV
700
PSGETPPSPS
710
QEGEEGSGLS
720
RPGEAGLGGQ
ER
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003700 | DNA-binding transcription factor activity |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0004969 | histamine receptor activity |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0060174 | limb bud formation |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0032332 | positive regulation of chondrocyte differentiation |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.