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Overview

Uniprot IDQ9QX60
Protein NameDeoxyguanosine kinase, mitochondrial
Gene NameDguok
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
135 GRLLQAEKSVRVFER

Function

Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine (PubMed:10455141). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs (PubMed:10455141). Widely used as target of antiviral and chemotherapeutic agents

Protein Sequence

10 MAAGRFLLRR 20 LRASFRSPLR 30 NALVDAPHAR 40 AMHDGGGPRR 50 LCIEGNIAVG 60 KSTFVKLLMK 70 THPEWQVATE 80 PIAEWQNIQA 90 AGAQKDGTSK 100 RLGNLLEMMY 110 QEPARWSYTF 120 QTLSFMSRLK 130 VQLEPIPGRL 140 LQAEKSVRVF 150 ERSVYSDRYI 160 FAKNLFENGS 170 LSDIEWHIYQ 180 DWHSFLLQEF 190 ANRLLLHGFI 200 YLQASPQVCM 210 ERLYQRDREE 220 EKGIELAYLQ 230 QLHSQHEDWF 240 INKTTKLHFE 250 ALQHVPVLVL 260 DVTEDFSENA 270 ARQEELMGQV NTFMRNL

Gene Ontology

Classification GO ID Description
Biological Process GO:0042775 mitochondrial ATP synthesis coupled electron transport
Biological Process GO:0010977 negative regulation of neuron projection development
Biological Process GO:0006139 nucleobase-containing compound metabolic process
Biological Process GO:0043173 nucleotide salvage
Biological Process GO:0006468 protein phosphorylation
Biological Process GO:0046122 purine deoxyribonucleoside metabolic process
Biological Process GO:0032261 purine nucleotide salvage
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0004136 deoxyadenosine kinase activity
Molecular Function GO:0004138 deoxyguanosine kinase activity
Molecular Function GO:0019136 deoxynucleoside kinase activity
Biological Process GO:0106383 dAMP salvage
Biological Process GO:0106384 dGMP salvage
Biological Process GO:0046070 dGTP metabolic process
Biological Process GO:0106385 dIMP salvage

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.