Search Results

Overview

Uniprot IDQ9QXS1
Protein NamePlectin
Gene NamePlec
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
1173 QRIAEQQKAQAEVEG
1183 AEVEGLGKGVARLSA
1726 AEVELQSKRASFAEK
2714 AEEGVRRKQEELQHL
3034 PLTDKAAKGGELVYT
578 IRLLASGKVAQRAGE

Function

Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics

Protein Sequence

10 MVAGMLMPLD 20 RLRAIYEVLF 30 REGVMVAKKD 40 RRPRSLHPHV 50 PGVTNLQVMR 60 AMASLKARGL 70 VRETFAWCHF 80 YWYLTNEGID 90 HLRQYLHLPP 100 EIVPASLQRV 110 RRPVAMVIPA 120 RRRSPHVQTM 130 QGPLGCPPKR 140 GPLPAEDPAR 150 EERQVYRRKE 160 REEGAPETPV 170 VSATTVGTLA 180 RPGPEPAPAT 190 DERDRVQKKT 200 FTKWVNKHLI 210 KHWRAEAQRH 220 ISDLYEDLRD 230 GHNLISLLEV 240 LSGDSLPREK 250 GRMRFHKLQN 260 VQIALDYLRH 270 RQVKLVNIRN 280 DDIADGNPKL 290 TLGLIWTIIL 300 HFQISDIQVS 310 GQSEDMTAKE 320 KLLLWSQRMV 330 EGYQGLRCDN 340 FTTSWRDGRL 350 FNAIIHRHKP 360 MLIDMNKVYR 370 QTNLENLDQA 380 FSVAERDLGV 390 TRLLDPEDVD 400 VPQPDEKSII 410 TYVSSLYDAM 420 PRVPGAQDGV 430 RANELQLRWQ 440 EYRELVLLLL 450 QWIRHHTAAF 460 EERKFPSSFE 470 EIEILWCQFL 480 KFKETELPAK 490 EADKNRSKVI 500 YQSLEGAVQA 510 GQLKIPPGYH 520 PLDVEKEWGK 530 LHVAILEREK 540 QLRSEFERLE 550 CLQRIVSKLQ 560 MEAGLCEEQL 570 NQADALLQSD 580 IRLLASGKVA 590 QRAGEVERDL 600 DKADGMIRLL 610 FNDVQTLKDG 620 RHPQGEQMYR 630 RVYRLHERLV 640 AIRTEYNLRL 650 KAGVGAPVTQ 660 VTLQSTQRRP 670 ELEDSTLRYL 680 QDLLAWVEEN 690 QRRIDSAEWG 700 VDLPSVEAQL 710 GSHRGMHQSI 720 EEFRAKIERA 730 RNDESQLSPA 740 TRGAYRDCLG 750 RLDLQYAKLL 760 NSSKARLRSL 770 ESLHGFVAAA 780 TKELMWLNEK 790 EEEEVGFDWS 800 DRNTNMAAKK 810 ESYSALMREL 820 EMKEKKIKEI 830 QNTGDRLLRE 840 DHPARPTVES 850 FQAALQTQWS 860 WMLQLCCCIE 870 AHLKENTAYF 880 QFFSDVREAE 890 EQLQKLQETL 900 RRKYSCDRTI 910 TVTRLEDLLQ 920 DAQDEKEQLN 930 EYKGHLSGLA 940 KRAKAIVQLK 950 PRNPAHPVRG 960 HVPLIAVCDY 970 KQVEVTVHKG 980 DQCQLVGPAQ 990 PSHWKVLSGS 1000 SSEAAVPSVC 1010 FLVPPPNQEA 1020 QEAVARLEAQ 1030 HQALVTLWHQ 1040 LHVDMKSLLA 1050 WQSLSRDIQL 1060 IRSWSLVTFR 1070 TLKPEEQRQA 1080 LRNLELHYQA 1090 FLRDSQDAGG 1100 FGPEDRLVAE 1110 REYGSCSRHY 1120 QQLLQSLEQG 1130 EQEESRCQRC 1140 ISELKDIRLQ 1150 LEACETRTVH 1160 RLRLPLDKDP 1170 ARECAQRIAE 1180 QQKAQAEVEG 1190 LGKGVARLSA 1200 EAEKVLALPE 1210 PSPAAPTLRS 1220 ELELTLGKLE 1230 QVRSLSAIYL 1240 EKLKTISLVI 1250 RSTQGAEEVL 1260 KTHEEQLKEA 1270 QAVPATLQEL 1280 EATKASLKKL 1290 RAQAEAQQPV 1300 FNTLRDELRG 1310 AQEVGERLQQ 1320 RHGERDVEVE 1330 RWRERVTQLL 1340 ERWQAVLAQT 1350 DVRQRELEQL 1360 GRQLRYYRES 1370 ADPLSAWLQD 1380 AKRRQEQIQA 1390 VPIANCQAAR 1400 EQLRQEKALL 1410 EEIERHGEKV 1420 EECQKFAKQY 1430 INAIKDYELQ 1440 LITYKAQLEP 1450 VASPAKKPKV 1460 QSGSESVIQE 1470 YVDLRTRYSE 1480 LTTLTSQYIK 1490 FISETLRRME 1500 EEERLAEQQR 1510 AEERERLAEV 1520 EAALEKQRQL 1530 AEAHAQAKAQ 1540 AELEAQELQR 1550 RMQEEVARRE 1560 EAAVDAQQQK 1570 RSIQEELQHL 1580 RQSSEAEIQA 1590 KAQQVEAAER 1600 SRMRIEEEIR 1610 VVRLQLETTE 1620 RQRGGAEGEL 1630 QALRARAEEA 1640 EAQKRQAQEE 1650 AERLRRQVQD 1660 ESQRKRQAEA 1670 ELALRVKAEA 1680 EAAREKQRAL 1690 QALDELRLQA 1700 EEAERRLRQA 1710 EAERARQVQV 1720 ALETAQRSAE 1730 VELQSKRASF 1740 AEKTAQLERT 1750 LQEEHVTVAQ 1760 LREEAERRAQ 1770 QQAEAERARE 1780 EAERELERWQ 1790 LKANEALRLR 1800 LQAEEVAQQK 1810 SLAQADAEKQ 1820 KEEAEREARR 1830 RGKAEEQAVR 1840 QRELAEQELE 1850 KQRQLAEGTA 1860 QQRLAAEQEL 1870 IRLRAETEQG 1880 EQQRQLLEEE 1890 LARLQHEATA 1900 ATQKRQELEA 1910 ELAKVRAEME 1920 VLLASKARAE 1930 EESRSTSEKS 1940 KQRLEAEAGR 1950 FRELAEEAAR 1960 LRALAEEAKR 1970 QRQLAEEDAA 1980 RQRAEAERVL 1990 TEKLAAISEA 2000 TRLKTEAEIA 2010 LKEKEAENER 2020 LRRLAEDEAF 2030 QRRRLEEQAA 2040 LHKADIEERL 2050 AQLRKASESE 2060 LERQKGLVED 2070 TLRQRRQVEE 2080 EIMALKVSFE 2090 KAAAGKAELE 2100 LELGRIRSNA 2110 EDTMRSKEQA 2120 ELEAARQRQL 2130 AAEEEQRRRE 2140 AEERVQRSLA 2150 AEEEAARQRK 2160 VALEEVERLK 2170 AKVEEARRLR 2180 ERAEQESARQ 2190 LQLAQEAAQK 2200 RLQAEEKAHA 2210 FVVQQREEEL 2220 QQTLQQEQNM 2230 LDRLRSEAEA 2240 ARRAAEEAEE 2250 AREQAEREAA 2260 QSRKQVEEAE 2270 RLKQSAEEQA 2280 QAQAQAQAAA 2290 EKLRKEAEQE 2300 AARRAQAEQA 2310 ALKQKQAADA 2320 EMEKHKKFAE 2330 QTLRQKAQVE 2340 QELTTLRLQL 2350 EETDHQKSIL 2360 DEELQRLKAE 2370 VTEAARQRSQ 2380 VEEELFSVRV 2390 QMEELGKLKA 2400 RIEAENRALI 2410 LRDKDNTQRF 2420 LEEEAEKMKQ 2430 VAEEAARLSV 2440 AAQEAARLRQ 2450 LAEEDLAQQR 2460 ALAEKMLKEK 2470 MQAVQEATRL 2480 KAEAELLQQQ 2490 KELAQEQARR 2500 LQEDKEQMAQ 2510 QLVEETQGFQ 2520 RTLEAERQRQ 2530 LEMSAEAERL 2540 KLRMAEMSRA 2550 QARAEEDAQR 2560 FRKQAEEIGE 2570 KLHRTELATQ 2580 EKVTLVQTLE 2590 IQRQQSDHDA 2600 ERLREAIAEL 2610 EREKEKLKQE 2620 AKLLQLKSEE 2630 MQTVQQEQIL 2640 QETQALQKSF 2650 LSEKDSLLQR 2660 ERFIEQEKAK 2670 LEQLFQDEVA 2680 KAKQLREEQQ 2690 RQQQQMEQEK 2700 QELMASMEEA 2710 RRRQREAEEG 2720 VRRKQEELQH 2730 LEQQRQQQEK 2740 LLAEENQRLR 2750 ERLQRLEEEH 2760 RAALAHSEIA 2770 TTQAASTKAL 2780 PNGRDAPDGP 2790 SVEAEPEYTF 2800 EGLRQKVPAQ 2810 QLQEAGILSQ 2820 EELQRLAQGH 2830 TTVAELTQRE 2840 DVYRYLKGRS 2850 SIAGLLLKPT 2860 NEKLSVYTAL 2870 QRQLLSPGTA 2880 LILLEAQAAS 2890 GFLLDPVRNR 2900 RLTVNEAVKE 2910 GVVGPELHHK 2920 LLSAERAVTG 2930 YKDPYTGEQI 2940 SLFQAMKKDL 2950 IVRDHGVRLL 2960 EAQIATGGII 2970 DPVHSHRVPV 2980 DVAYKRGYFD 2990 EEMNRILSDP 3000 SDDTKGFFDP 3010 NTHENLTYLQ 3020 LLERCVEDPE 3030 TGLRLLPLTD 3040 KAAKGGELVY 3050 TDTEARDVFE 3060 KATVSAPFGK 3070 FQGRTVTIWE 3080 IINSEYFTAE 3090 QRRDLLQQFR 3100 TGHITVEKII 3110 KIVITVVEEH 3120 ERKGQLCFEG 3130 LRALVPAAEL 3140 LDSGVISHEL 3150 YQQLQRGERS 3160 VREVAEADSV 3170 RQALRGTNVI 3180 AGVWLEEAGQ 3190 KLSIYEALKK 3200 DLLQPEVAVA 3210 LLEAQAGTGH 3220 IIDPATSARL 3230 TVDEAVRAGL 3240 VGPELHEKLL 3250 SAEKAVTGYR 3260 DPYSGQSVSL 3270 FQALKKGLIP 3280 REQGLRLLDA 3290 QLSTGGIVDP 3300 SKSHRVPLDV 3310 AYARGYLDKE 3320 TNRALTSPRD 3330 DARVYHDPST 3340 QEPVTYSQLQ 3350 QRCRSDQLTG 3360 LSLLPLSEKA 3370 VRARQEEVYS 3380 ELQARETLEQ 3390 AKVEVPVGSF 3400 KGRAMTVWEL 3410 ISSEYFTEEQ 3420 RQELLRQFRT 3430 GKVTVEKVIK 3440 IVITIVEEVE 3450 TRRQERLSFS 3460 GLRAPVPASE 3470 LLDAKILSRA 3480 QFDQLKDGKT 3490 SVKELSEVGS 3500 VRTLLQGSGC 3510 LAGIYLEDSK 3520 EKVTIYEAMR 3530 RGLLRPSTAT 3540 LLLEAQAATG 3550 FLVDPVRNQR 3560 LYVHEAVKAG 3570 VVGPELHEKL 3580 LSAEKAVTGY 3590 KDPYSGNTIS 3600 LFQAMKKGLV 3610 LRDHAIRLLE 3620 AQVATGGIID 3630 PVHSHRLPVD 3640 VAYQRGYFDE 3650 EMNRVLADPS 3660 DDTKGFFDPN 3670 THENLTYLQL 3680 LERCVEDPET 3690 GLRLLPLKGA 3700 EKTEVVETTQ 3710 VYTEEETRRA 3720 FEETQIDIPG 3730 GGSHGGSSMS 3740 LWEVMQSNMI 3750 PEDQRARLMA 3760 DFQAGRVTKE 3770 RMIIIIIEII 3780 EKTEIIRQQN 3790 LASYDYVRRR 3800 LTAEDLYEAR 3810 IISLETYNLF 3820 REGTKNLREV 3830 LEMESAWRYL 3840 YGTGAVAGVY 3850 LPGSRQTLTI 3860 YQALKKGLLS 3870 AEVARLLLEA 3880 QAATGFLLDP 3890 VKGERLTVDE 3900 AVRKGLVGPE 3910 LHDRLLSAER 3920 AVTGYRDPYT 3930 EQTISLFQAM 3940 KKELIPAEEA 3950 LRLLDAQLAT 3960 GGIVDPRLGF 3970 HLPLEVAYQR 3980 GYLNKDTHDQ 3990 LSEPSEVRSY 4000 VDPSTDERLS 4010 YTQLLKRCRR 4020 DDPSGQMLLL 4030 LSDARKLTFR 4040 GLRKQITVEE 4050 LVRSQVMDEA 4060 TALQLQEGLT 4070 SIEEVTKNLQ 4080 KFLEGTSCIA 4090 GVFVDATKER 4100 LSVYQAMKKG 4110 IIRPGTAFEL 4120 LEAQAATGYV 4130 IDPIKGLKLT 4140 VEEAVRMGIV 4150 GPEFKDKLLS 4160 AERAVTGYKD 4170 PYSGKLISLF 4180 QAMKKGLILK 4190 DHGIRLLEAQ 4200 IATGGIIDPE 4210 ESHRLPVEVA 4220 YKRGLFDEEM 4230 NEILTDPSDD 4240 TKGFFDPNTE 4250 ENLTYLQLME 4260 RCITDPQTGL 4270 CLLPLKEKKR 4280 ERKTSSKSSV 4290 RKRRVVIVDP 4300 ETGKEMSVYE 4310 AYRKGLIDHQ 4320 TYLELSEQEC 4330 EWEEITISSS 4340 DGVVKSMIID 4350 RRSGRQYDID 4360 DAITKNLIDR 4370 SALDQYRAGT 4380 LSITEFADML 4390 SGNAGGFRSR 4400 SSSVGSSSSY 4410 PISSAGPRTQ 4420 LASWSDPTEE 4430 TGPVAGILDT 4440 ETLEKVSITE 4450 AMHRNLVDNI 4460 TGQRLLEAQA 4470 CTGGIIDPST 4480 GERFPVTEAV 4490 NKGLVDKIMV 4500 DRINLAQKAF 4510 CGFEDPRTKT 4520 KMSAAQALKK 4530 GWLYYEAGQR 4540 FLEVQYLTGG 4550 LIEPDTPGRV 4560 SLDEALQRGT 4570 VDARTAQKLR 4580 DVSAYSKYLT 4590 CPKTKLKISY 4600 KDALDRSMVE 4610 EGTGLRLLEA 4620 AAQSSKGYYS 4630 PYSVSGSGST 4640 AGSRTGSRTG 4650 SRAGSRRGSF 4660 DATGSGFSMT 4670 FSSSSYSSSG 4680 YGRRYASGPS 4690 ASLGGPESAV A

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030425 dendrite
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0030056 hemidesmosome
Cellular Component GO:0045111 intermediate filament cytoskeleton
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0043209 myelin sheath
Cellular Component GO:0030016 myofibril
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0002102 podosome
Cellular Component GO:0042383 sarcolemma
Cellular Component GO:0016528 sarcoplasm
Cellular Component GO:0030018 Z disc
Molecular Function GO:0003779 actin binding
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0030506 ankyrin binding
Molecular Function GO:0008092 cytoskeletal protein binding
Molecular Function GO:0002162 dystroglycan binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Molecular Function GO:0008307 structural constituent of muscle
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0007015 actin filament organization
Biological Process GO:2000689 actomyosin contractile ring assembly actin filament organization
Biological Process GO:0034332 adherens junction organization
Biological Process GO:0055013 cardiac muscle cell development
Biological Process GO:0000902 cell morphogenesis
Biological Process GO:0048870 cell motility
Biological Process GO:0071498 cellular response to fluid shear stress
Biological Process GO:0071464 cellular response to hydrostatic pressure
Biological Process GO:0071260 cellular response to mechanical stimulus
Biological Process GO:0061436 establishment of skin barrier
Biological Process GO:0010761 fibroblast migration
Biological Process GO:0010467 gene expression
Biological Process GO:0031581 hemidesmosome assembly
Biological Process GO:0045104 intermediate filament cytoskeleton organization
Biological Process GO:0045109 intermediate filament organization
Biological Process GO:0008104 intracellular protein localization
Biological Process GO:0003334 keratinocyte development
Biological Process GO:0030216 keratinocyte differentiation
Biological Process GO:0002522 leukocyte migration involved in immune response
Biological Process GO:0007005 mitochondrion organization
Biological Process GO:0035264 multicellular organism growth
Biological Process GO:0022011 myelination in peripheral nervous system
Biological Process GO:0045445 myoblast differentiation
Biological Process GO:0006469 negative regulation of protein kinase activity
Biological Process GO:0006997 nucleus organization
Biological Process GO:0032287 peripheral nervous system myelin maintenance
Biological Process GO:0043933 protein-containing complex organization
Biological Process GO:2000983 regulation of ATP citrate synthase activity
Biological Process GO:0043114 regulation of vascular permeability
Biological Process GO:0022904 respiratory electron transport chain
Biological Process GO:0032094 response to food
Biological Process GO:0007584 response to nutrient
Biological Process GO:0045214 sarcomere organization
Biological Process GO:0048741 skeletal muscle fiber development
Biological Process GO:0007519 skeletal muscle tissue development
Biological Process GO:0014866 skeletal myofibril assembly
Biological Process GO:0043588 skin development
Biological Process GO:0010818 T cell chemotaxis
Biological Process GO:0120193 tight junction organization
Biological Process GO:0019226 transmission of nerve impulse
Biological Process GO:0042060 wound healing
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0030424 axon
Cellular Component GO:0009925 basal plasma membrane
Cellular Component GO:0005903 brush border
Cellular Component GO:0071944 cell periphery
Cellular Component GO:0043292 contractile muscle fiber
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.