Search Results
Overview
| Uniprot ID | Q9QY76 |
|---|---|
| Protein Name | Vesicle-associated membrane protein-associated protein B |
| Gene Name | Vapb |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 147 | IIPTSASKTEAPAAA |
Function
Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. Interacts with STARD3 in a FFAT motif phosphorylation dependent manner. Via interaction with WDR44 participates in neosynthesized protein export. Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation
Protein Sequence
10
MAKVEQVLSL
20
EPQHELKFRG
30
PFTDVVTTNL
40
KLGNPTDRNV
50
CFKVKTTVPR
60
RYCVRPNSGV
70
IDAGASLNVS
80
VMLQPFDYDP
90
NEKSKHKFMV
100
QSMFAPPDTS
110
DMEAVWKEAK
120
PEDLMDSKLR
130
CVFELPAENA
140
KPHDVEINKI
150
IPTSASKTEA
160
PAAAKSLTSP
170
LDDTEVKKVM
180
EECRRLQGEV
190
QRLREESRQL
200
KEEDGLRVRK
210
AMPSNSPVAA
220
LAATGKEEGL
230
SARLLALVVL
240
FFIVGVIIGK
IAL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0098793 | presynapse |
| Molecular Function | GO:0048487 | beta-tubulin binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0033149 | FFAT motif binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0043495 | protein-membrane adaptor activity |
| Biological Process | GO:0030301 | cholesterol transport |
| Biological Process | GO:0090114 | COPII-coated vesicle budding |
| Biological Process | GO:0090158 | endoplasmic reticulum membrane organization |
| Biological Process | GO:0007029 | endoplasmic reticulum organization |
| Biological Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Biological Process | GO:0030968 | endoplasmic reticulum unfolded protein response |
| Biological Process | GO:0061817 | endoplasmic reticulum-plasma membrane tethering |
| Biological Process | GO:0044829 | host-mediated activation of viral genome replication |
| Biological Process | GO:0044830 | host-mediated perturbation of viral RNA genome replication |
| Biological Process | GO:0044828 | host-mediated suppression of viral genome replication |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:0036498 | IRE1-mediated unfolded protein response |
| Biological Process | GO:0046725 | negative regulation by virus of viral protein levels in host cell |
| Biological Process | GO:0045070 | positive regulation of viral genome replication |
| Biological Process | GO:0044790 | suppression of viral release by host |
| Biological Process | GO:0019076 | viral release from host cell |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.