Search Results
Overview
| Uniprot ID | Q9QYG0 |
|---|---|
| Protein Name | Protein NDRG2 |
| Gene Name | Ndrg2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 277 | AVVECNSKLDPTQTS |
Function
Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity)
Protein Sequence
10
MAELQEVQIT
20
EEKPLLPGQT
30
PETAKEAELA
40
ARILLDQGQT
50
HSVETPYGSV
60
TFTVYGTPKP
70
KRPAIFTYHD
80
VGLNYKSCFQ
90
PLFRFGDMQE
100
IIQNFVRVHV
110
DAPGMEEGAP
120
VFPLGYQYPS
130
LDQLADMIPC
140
ILQYLNFSTI
150
IGVGVGAGAY
160
ILSRYALNHP
170
DTVEGLVLIN
180
IDPNAKGWMD
190
WAAHKLTGLT
200
SSIPDMILGH
210
LFSQEELSGN
220
SELIQKYRGI
230
IQHAPNLENI
240
ELYWNSYNNR
250
RDLNFERGGE
260
TTLKCPVMLV
270
VGDQAPHEDA
280
VVECNSKLDP
290
TQTSFLKMAD
300
SGGQPQLTQP
310
GKLTEAFKYF
320
LQGMGYMASS
330
CMTRLSRSRT
340
ASLTSAASID
350
GSRSRSRTLS
360
QSSESGTLPS
370
GPPGHTMEVS
C
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0001818 | negative regulation of cytokine production |
| Biological Process | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0048662 | negative regulation of smooth muscle cell proliferation |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0090361 | regulation of platelet-derived growth factor production |
| Biological Process | GO:0010574 | regulation of vascular endothelial growth factor production |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0016055 | Wnt signaling pathway |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.