Search Results
Overview
| Uniprot ID | Q9QYR9 |
|---|---|
| Protein Name | Acyl-coenzyme A thioesterase 2, mitochondrial |
| Gene Name | Acot2 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 263 | LRSHPEVKGPGIGLL |
| 344 | LQSPLVDKKSFIPVE |
| 345 | QSPLVDKKSFIPVER |
| 379 | FYADEISKRLQAHGK |
| 83 | RSALRDEKGALFRAH |
Function
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:25114170). Displays higher activity toward long chain acyl CoAs (C14-C20) (PubMed:25114170). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (PubMed:25114170)
Protein Sequence
10
MVASSFAVLR
20
ASRLCQQDWK
30
SWARLFVPPP
40
LSTGGRTTWA
50
RTNATLSVEP
60
EGRSCWDEPL
70
SIAVRGLAPE
80
QPVTLRSALR
90
DEKGALFRAH
100
ARYRADAGGE
110
LNLARAPALG
120
GSFSGLEPMG
130
LLWAMEPERP
140
LWRLIKRDVQ
150
TPFLVELEVL
160
DGHEPDGGQR
170
LAQAVHERHF
180
LAPGVRRVPV
190
REGRVRATLF
200
LPPEPGPFPG
210
IIDLFGVGGG
220
LLEYRASLLA
230
GKGFAVMALA
240
YYNYDDLPKS
250
IETMHMEYFE
260
EAVNYLRSHP
270
EVKGPGIGLL
280
GISKGGELGL
290
AMASFLKGIT
300
AAVVINGSVA
310
AVGNTISYKD
320
ETIPPVSLLR
330
NQVKMTKDGL
340
LDVVEALQSP
350
LVDKKSFIPV
360
ERSDTTFLFL
370
VGQDDHNWKS
380
EFYADEISKR
390
LQAHGKEKPQ
400
IICYPAAGHY
410
IEPPYFPLCS
420
AGMHLLVGAN
430
ITFGGEPRAH
440
AVAQVDAWQQ
450
LQTFFHKQLG
SKS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0052689 | carboxylic ester hydrolase activity |
| Molecular Function | GO:0047617 | fatty acyl-CoA hydrolase activity |
| Molecular Function | GO:0052816 | long-chain fatty acyl-CoA hydrolase activity |
| Biological Process | GO:0006637 | acyl-CoA metabolic process |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0001676 | long-chain fatty acid metabolic process |
| Biological Process | GO:0036116 | long-chain fatty-acyl-CoA catabolic process |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0000038 | very long-chain fatty acid metabolic process |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.