Search Results
Overview
| Uniprot ID | Q9QZ47 |
|---|---|
| Protein Name | Troponin T, fast skeletal muscle |
| Gene Name | Tnnt3 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 107 | EEELIALKERIEKRR |
| 198 | KILAERRKPLNIDHL |
| 209 | IDHLSDDKLRDKAKE |
| 56 | EEEKPRPKLTAPKIP |
| 61 | RPKLTAPKIPEGEKV |
| 67 | PKIPEGEKVDFDDIQ |
| 75 | VDFDDIQKKRQNKDL |
| 97 | DSHFEARKKEEEELI |
| 98 | SHFEARKKEEEELIA |
Function
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity
Protein Sequence
10
MSDEETEQVE
20
EQYEEEEEAQ
30
EEEVQEEAPE
40
PEEVQEDAVA
50
EEEREEDEEE
60
EKPRPKLTAP
70
KIPEGEKVDF
80
DDIQKKRQNK
90
DLMELQALID
100
SHFEARKKEE
110
EELIALKERI
120
EKRRAERAEQ
130
QRIRAEKERE
140
PQNRLAEEKA
150
RREEEDAKRR
160
AEDDMKKKKA
170
LSSMGANYSS
180
YLAKADQKRG
190
KKQTAREMKK
200
KILAERRKPL
210
NIDHLSDDKL
220
RDKAKELWDT
230
LYQLETDKFE
240
FGEKLKRQKY
250
DITTLRSRID
260
QAQKHSKKAG
270
ATAKGKVGGR
WK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005861 | troponin complex |
| Molecular Function | GO:0048306 | calcium-dependent protein binding |
| Molecular Function | GO:0005523 | tropomyosin binding |
| Molecular Function | GO:0030172 | troponin C binding |
| Molecular Function | GO:0031013 | troponin I binding |
| Biological Process | GO:1903612 | positive regulation of calcium-dependent ATPase activity |
| Biological Process | GO:0043462 | regulation of ATP-dependent activity |
| Biological Process | GO:0006942 | regulation of striated muscle contraction |
| Biological Process | GO:0045214 | sarcomere organization |
| Biological Process | GO:0003009 | skeletal muscle contraction |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.