Search Results
Overview
| Uniprot ID | Q9R0P5 |
|---|---|
| Protein Name | Destrin |
| Gene Name | Dstn |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 19 | CRIFYDMKVRKCSTP |
| 22 | FYDMKVRKCSTPEEI |
Function
Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner
Protein Sequence
10
MASGVQVADE
20
VCRIFYDMKV
30
RKCSTPEEIK
40
KRKKAVIFCL
50
SADKKCIVVE
60
EGKEILVGDV
70
GATITDPFKH
80
FVGMLPEKDC
90
RYALYDASFE
100
TKESRKEELM
110
FFLWAPEQAP
120
LKSKMIYASS
130
KDAIKKKFPG
140
IKHEYQANGP
150
EDLNRTCIAE
160
KLGGSLIVAF
EGSPV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0030864 | cortical actin cytoskeleton |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0098793 | presynapse |
| Molecular Function | GO:0051015 | actin filament binding |
| Biological Process | GO:0030042 | actin filament depolymerization |
| Biological Process | GO:0030043 | actin filament fragmentation |
| Biological Process | GO:0051014 | actin filament severing |
| Biological Process | GO:0048870 | cell motility |
| Biological Process | GO:0030836 | positive regulation of actin filament depolymerization |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.