Search Results

Overview

Uniprot IDQ9R0Y5
Protein NameAdenylate kinase isoenzyme 1
Gene NameAk1
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
100 DGYPREVKQGEEFEQ
21 VGGPGSGKGTQCEKI
27 GKGTQCEKIVQKYGY
31 QCEKIVQKYGYTHLS
56 SGSERGKKLSAIMEK
9 EEKLKKAKIIFVVGG

Function

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP (By similarity)

Protein Sequence

10 MEEKLKKAKI 20 IFVVGGPGSG 30 KGTQCEKIVQ 40 KYGYTHLSTG 50 DLLRAEVSSG 60 SERGKKLSAI 70 MEKGELVPLD 80 TVLDMLRDAM 90 LAKVDSSNGF 100 LIDGYPREVK 110 QGEEFEQKIG 120 QPTLLLYVDA 130 GAETMTQRLL 140 KRGETSGRVD 150 DNEETIKKRL 160 ETYYNATEPV 170 ISFYDKRGIV 180 RKVNAEGTVD 190 TVFSEVCTYL DSLK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0001520 outer dense fiber
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0030017 sarcomere
Cellular Component GO:0036126 sperm flagellum
Molecular Function GO:0004017 AMP kinase activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0047506 dAMP kinase activity
Molecular Function GO:0004550 nucleoside diphosphate kinase activity
Biological Process GO:0006172 ADP biosynthetic process
Biological Process GO:0046033 AMP metabolic process
Biological Process GO:0046034 ATP metabolic process
Biological Process GO:0046103 inosine biosynthetic process
Biological Process GO:0009142 nucleoside triphosphate biosynthetic process
Biological Process GO:0010828 positive regulation of D-glucose transmembrane transport
Biological Process GO:2000045 regulation of G1/S transition of mitotic cell cycle

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.