Search Results
Overview
| Uniprot ID | Q9R112 |
|---|---|
| Protein Name | Sulfide:quinone oxidoreductase, mitochondrial |
| Gene Name | Sqor |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 173 | IGSNYSVKTVEKTWK |
Function
Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). It is believed the in vivo electron acceptor is glutathione
Protein Sequence
10
MAPLVTVVSS
20
PRARLFACFL
30
RLGTQQAGPL
40
QLHTGACCTA
50
KNHYEVLVLG
60
GGAGGITMAT
70
RMKRRVGAEN
80
VAIVEPSERH
90
FYQPIWTLVG
100
AGAKELSLSV
110
RSTLSVIPSG
120
VQWIQDRVAE
130
LNPDENCIRT
140
DSGKEISYRY
150
LIIALGIQLD
160
YEKIKGLPEG
170
FAYPKIGSNY
180
SVKTVEKTWK
190
ALQGFKEGNA
200
LFTFPNTPVK
210
CAGAPQKIMY
220
LSEAYFRKTG
230
KRPKANIIFN
240
TALGTIFGVK
250
KYADALQEII
260
RERDVSVNYK
270
HNLIEVRPDK
280
QEAVFEILDK
290
PGETHVIPYE
300
MLHVTPPMSA
310
PDVLKRSPVA
320
DSAGWVDVDK
330
ETLQHKKYPN
340
VFGIGDCTNL
350
PTSKTAAAVA
360
AQSGILDRTM
370
CLIMKNQRPI
380
KKYDGYTSCP
390
LVTGYNRVIL
400
AEFDYTAQPL
410
ETFPFDQSKE
420
RITMYLMKAD
430
MMPFLYWNMM
440
LRGYWGGPAF
450
LRKLFHLGMN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0071949 | FAD binding |
| Molecular Function | GO:0106436 | glutathione-dependent sulfide quinone oxidoreductase activity |
| Molecular Function | GO:0048038 | quinone binding |
| Molecular Function | GO:0070224 | sulfide:quinone oxidoreductase activity |
| Biological Process | GO:0070221 | sulfide oxidation, using sulfide:quinone oxidoreductase |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.