Overview
| Uniprot ID | Q9R1P4 |
|---|
| Protein Name | Proteasome subunit alpha type-1 |
|---|
| Gene Name | Psma1 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 243 |
LEERPQRKAQPSQAA |
Function
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)
Protein Sequence
10
MFRNQYDNDV
20
TVWSPQGRIH
30
QIEYAMEAVK
40
QGSATVGLKS
50
KTHAVLVALK
60
RAQSELAAHQ
70
KKILHVDNHI
80
GISIAGLTAD
90
ARLLCNFMRQ
100
ECLDSRFVFD
110
RPLPVSRLVS
120
LIGSKTQIPT
130
QRYGRRPYGV
140
GLLIAGYDDM
150
GPHIFQTCPS
160
ANYFDCRAMS
170
IGARSQSART
180
YLERHMSEFM
190
ECNLDELVKH
200
GLRALRETLP
210
AEQDLTTKNV
220
SIGIVGKDLE
230
FTIYDDDDVS
240
PFLDGLEERP
250
QRKAQPSQAA
260
EEPAEKADEP
MEH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0016604 |
nuclear body |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0000502 |
proteasome complex |
| Cellular Component |
GO:0005839 |
proteasome core complex |
| Cellular Component |
GO:0019773 |
proteasome core complex, alpha-subunit complex |
| Molecular Function |
GO:0001530 |
lipopolysaccharide binding |
| Biological Process |
GO:0002376 |
immune system process |
| Biological Process |
GO:0002862 |
negative regulation of inflammatory response to antigenic stimulus |
| Biological Process |
GO:0010498 |
proteasomal protein catabolic process |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0061136 |
regulation of proteasomal protein catabolic process |
| Biological Process |
GO:0006979 |
response to oxidative stress |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.