Overview
| Uniprot ID | Q9TSX9 |
|---|
| Protein Name | Peroxiredoxin-6 |
|---|
| Gene Name | PRDX6 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 209 |
FPKGVFTKELPSGKK |
| 56 |
TELGRAAKLAPEFAK |
| 63 |
KLAPEFAKRNVKMIA |
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (By similarity). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides (By similarity). Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (By similarity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (By similarity). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (By similarity). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (By similarity). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (By similarity)
Protein Sequence
10
MPGGLLLGDE
20
APNFEANTTI
30
GRIRFHDFLG
40
DSWGILFSHP
50
RDFTPVCTTE
60
LGRAAKLAPE
70
FAKRNVKMIA
80
LSIDSVEDHL
90
AWSKDINAYN
100
GEEPKETLPF
110
PIIDDKSRDL
120
AIQLGMLDPA
130
EKDEQGMPVT
140
ARVVFIFGPD
150
KKLKLSILYP
160
ATTGRNFDEI
170
LRVIISLQLT
180
AEKRVATPVD
190
WKNGDSVMVL
200
PNIPEEEAKK
210
LFPKGVFTKE
220
LPSGKKYLRY
TPQP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005764 |
lysosome |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Molecular Function |
GO:0047184 |
1-acylglycerophosphocholine O-acyltransferase activity |
| Molecular Function |
GO:0004623 |
A2-type glycerophospholipase activity |
| Molecular Function |
GO:0004602 |
glutathione peroxidase activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0004601 |
peroxidase activity |
| Molecular Function |
GO:0051920 |
peroxiredoxin activity |
| Molecular Function |
GO:0031625 |
ubiquitin protein ligase binding |
| Biological Process |
GO:0045454 |
cell redox homeostasis |
| Biological Process |
GO:0046475 |
glycerophospholipid catabolic process |
| Biological Process |
GO:0048026 |
positive regulation of mRNA splicing, via spliceosome |
| Biological Process |
GO:0006979 |
response to oxidative stress |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.