Overview
| Uniprot ID | Q9TUB2 |
|---|
| Protein Name | Cellular tumor antigen p53 |
|---|
| Gene Name | TP53 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 112 |
FLHSGTAKSVTCTYS |
| 284 |
TEEENFLKKGQSCPE |
| 285 |
EEENFLKKGQSCPEP |
| 312 |
TSSSPVQKKKPLDGE |
Function
Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively reQ9TUB2lates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 (By similarity). However, this activity is inhibited when the interaction with PPP1R13B/ASPP1 or TP53BP2/ASPP2 is displaced by PPP1R13L/iASPP (By similarity). In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2
Protein Sequence
10
MEESQSELGV
20
EPPLSQETFS
30
DLWKLLPENN
40
LLSSELSLAA
50
VNDLLLSPVT
60
NWLDENPDDA
70
SRVPAPPAAT
80
APAPAAPAPA
90
TSWPLSSFVP
100
SQKTYPGSYD
110
FRLGFLHSGT
120
AKSVTCTYSP
130
ALNKLFCQLA
140
KTCPVQLWVS
150
SPPPPGTRVR
160
AMAIYKKSEY
170
MTEVVRRCPH
180
HERSSDYSDG
190
LAPPQHLIRV
200
EGNLRAEYLD
210
DRNTFRHSVV
220
VPYEPPEVGS
230
DCTTIHYNFM
240
CNSSCMGGMN
250
RRPILTIITL
260
EDASGNLLGR
270
NSFEVRVCAC
280
PGRDRRTEEE
290
NFLKKGQSCP
300
EPPPGSTKRA
310
LPTSTSSSPV
320
QKKKPLDGEY
330
FTLQIRGRER
340
FEMFRELNDA
350
LELKDAQTAR
360
ESGENRAHSS
370
HLKSKKGQSP
380
SRHKKPMFKR
EGPDSD
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:0042981 |
regulation of apoptotic process |
| Biological Process |
GO:0090276 |
regulation of peptide hormone secretion |
| Biological Process |
GO:0032306 |
regulation of prostaglandin secretion |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0016605 |
PML body |
| Molecular Function |
GO:0036310 |
ATP-dependent DNA/DNA annealing activity |
| Molecular Function |
GO:0005507 |
copper ion binding |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0000981 |
DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function |
GO:0140693 |
molecular condensate scaffold activity |
| Molecular Function |
GO:1990841 |
promoter-specific chromatin binding |
| Molecular Function |
GO:0000978 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Biological Process |
GO:0090398 |
cellular senescence |
| Biological Process |
GO:0048512 |
circadian behavior |
| Biological Process |
GO:0006974 |
DNA damage response |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0043153 |
entrainment of circadian clock by photoperiod |
| Biological Process |
GO:0042771 |
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| Biological Process |
GO:0030308 |
negative regulation of cell growth |
| Biological Process |
GO:0045892 |
negative regulation of DNA-templated transcription |
| Biological Process |
GO:2000871 |
negative regulation of progesterone secretion |
| Biological Process |
GO:0006289 |
nucleotide-excision repair |
| Biological Process |
GO:0097252 |
oligodendrocyte apoptotic process |
| Biological Process |
GO:0043065 |
positive regulation of apoptotic process |
| Biological Process |
GO:2001244 |
positive regulation of intrinsic apoptotic signaling pathway |
| Biological Process |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0051262 |
protein tetramerization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.